RT Journal Article T1 Myocardial Work Index in Professional Football Players: A Novel Method for Assessment of Cardiac Adaptation A1 Refoyo, Elena A1 Troya, Jesús A1 Fuente, Ana de la A1 Beltrán, Almudena A1 Celada, Oscar Luis A1 Díaz González, Leonel A1 Pedrero Tomé, Roberto A1 García Yébenes, Manuel A1 Villalón, Jose María AB Background: The global myocardial work index (GWI), a novel, valid, and non-invasive method based on speckle-tracking echocardiography, could provide value for calculating left ventricular (LV) function and energy consumption in athletes.Materials and methods: We prospectively analyzed a single-center cohort of Spanish First-Division football players who attended a pre-participation screening program from June 2020 to June 2021, compared to a control group. All the individuals underwent an electrocardiogram and echocardiography, including two-dimensional speckle tracking and 4D-echo. The study aimed to evaluate the feasibility of myocardial work in professional football players and its correlations with other echocardiographic parameters.Results: The study population comprised 97 individuals (49 professional players and 48 controls). The mean age was 30.48 ± 7.20 years old. The professional football players had significantly higher values of LVEDV (p < 0.001), LVESV (p < 0.001), LV-mass index (p = 0.011), PWTd (p = 0.023), and EA (p < 0.001) compared with the control group. In addition, the professional players had lower GCW (p = 0.003) and a tendency to show lower GWI values (p < 0.001). These findings could suggest that professional football players have more remodeling and less MW, related to their adaptation to intensive training. Significant differences in GLS (p = 0.01) and GWE (p = 0.04) were observed as a function of the septal thickness of the athletes. Irrespective of the MW variable, the parameters with better correlations across all the populations were SBP, DBP, and GLS.Conclusions: The GWI is a novel index to assess cardiac performance, with less load dependency than strain measurements. Future GWI analyses are warranted to understand myocardial deformation and other pathological differential diagnoses. PB MPDI YR 2023 FD 2023-04-23 LK https://hdl.handle.net/20.500.14352/103443 UL https://hdl.handle.net/20.500.14352/103443 LA eng NO Refoyo E, Troya J, de la Fuente A, Beltrán A, Celada OL, Díaz-González L, Pedrero-Tomé R, García-Yébenes M, Villalón JM. Myocardial Work Index in Professional Football Players: A Novel Method for Assessment of Cardiac Adaptation. J Clin Med. 2023 Apr 23;12(9):3059. doi: 10.3390/jcm12093059. PMID: 37176500; PMCID: PMC10179020. DS Docta Complutense RD 4 abr 2025