RT Journal Article
T1 Sodium caseinate stabilized emulsions as a delivery system for epigallocatechin-gallate: Bioaccessibility, anti-proliferative activity and intestinal absorption
A1 Sabouri, Somayeh
A1 Arranz Gutiérrez, Elena María
A1 Corredig, Milena
A1 Guri, Anilda
AB The objective of this study was to investigate the effect of complexation of epigallocatechin-gallate (EGCG) to a caseinate-stabilized oil-water interface on the bioefficacy of EGCG. The bioaccessibility, anti-proliferative activity, and intestinal uptake of EGCG are reported. Higher amount of EGCG was present in digested emulsions compared to their equivalent solutions after digestion. The incorporation of EGCG in sodium caseinate emulsions improved its bioaccesibility and this was confirmed by cytotoxicity assays on Caco-2 cells. Intestinal absorption of EGCG was also studied with in vitro transport experiments. It was difficult to obtain a quantitative measurement of the EGCG in the basolateral fraction, but the fractions showed a clear anti-proliferative activity. These results would suggest the use of a cytotoxicity assay on cell cultures to estimate the extent of intestinal absorption of the bioactive catechin EGCG. The findings demonstrated that sodium caseinate-stabilized emulsions can be used as a platform for delivery of EGCG.
PB Elsevier
SN 1756-4646
YR 2018
FD 2018-03-23
LK https://hdl.handle.net/20.500.14352/92985
UL https://hdl.handle.net/20.500.14352/92985
LA eng
NO Sabouri, S., Arranz, E., Guri, A., & Corredig, M. (2018). Sodium caseinate stabilized emulsions as a delivery system for epigallocatechin-gallate: Bioaccessibility, anti-proliferative activity and intestinal absorption. Journal of Functional Foods, 44, 166-172
NO Natural Sciences and Engineering Research Council of Canada
NO EU COST Action INFOGEST
DS Docta Complutense
RD 6 abr 2025