TY  - JOUR
AU  - Caballero Collado, Ricardo
AU  - Dolz Gaitón, Pablo
AU  - Gómez García, Ricardo
AU  - Amorós García, Irene
AU  - Barana Muñoz, Adriana
AU  - González de la Fuente, Marta
AU  - Osuna, Lourdes
AU  - Duarte, Juan
AU  - López Izquierdo, Angélica
AU  - Moraleda, Ignacio
AU  - Gálvez Ruano, Enrique
AU  - Sánchez Chapula, José Antonio
AU  - Tamargo Menéndez, Juan
AU  - Delpón Mosquera, María Eva
PY  - 2010
DO  - 10.1073/pnas.1004021107
SN  - 0027-8424
UR  - https://hdl.handle.net/20.500.14352/92209
T2  - Proceedings of the National Academy of Sciences (PNAS)
AB  - Both increase and decrease of cardiac inward rectifier current (I(K1)) are associated with severe cardiac arrhythmias. Flecainide, a widely used antiarrhythmic drug, exhibits ventricular proarrhythmic effects while effectively controlling ventricular...
LA  - eng
M2  - 15631
PB  - National Academy of Sciences
KW  - Cardiac IK1
KW  - Kir2.2 channel
KW  - Kir2.3 channel
KW  - Andersen mutations
KW  - Inwardrectifying channel
TI  - Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification
TY  - journal article
VL  - 107
ER  -