RT Journal Article
T1 Iron overload, measured as serum ferritin, increases brain damage induced by focal ischemia and early reperfusion
A1 García Yébenes, Isaac
A1 Sobrado, Mónica
A1 Moraga Yébenes, Ana
A1 Zarruk, Juan
A1 Romera, Victor
A1 Pradillo Justo, Jesús Miguel
A1 Pérez de la Ossa, Natalia
A1 Moro Sánchez, María Ángeles
A1 Dávalos, Antoni
A1 Lizasoaín Hernández, Ignacio
AB High levels of iron, measured as serum ferritin, are associated to a worse outcome after stroke. However, it is not known whether ischemic damage might increase ferritin levels as an acute phase protein or whether iron overload affects stroke outcome. The objectives are to study the effect of stroke on serum ferritin and the contribution of iron overload to ischemic damage. Swiss mice were fed with a standard diet or with a diet supplemented with 2.5% carbonyl iron to produce iron overload. Mice were submitted to permanent (by ligature and by in situ thromboembolic models) or transient focal ischemia (by ligature for 1 or 3h). Treatment with iron diet produced an increase in the basal levels of ferritin in all the groups. However, serum ferritin did not change after ischemia. Animals submitted to permanent ischemia had the same infarct volume in the groups studied. However, in mice submitted to transient ischemia followed by early (1h) but not late reperfusion (3h), iron overload increased ischemic damage and haemorrhagic transformation. Iron worsens ischemic damage induced by transient ischemia and early reperfusion. In addition, ferritin is a good indicator of body iron levels but not an acute phase protein after ischemia.
PB Elsevier
SN 0197-0186
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/96281
UL https://hdl.handle.net/20.500.14352/96281
LA eng
NO García-Yébenes I, Sobrado M, Moraga A, Zarruk JG, Romera VG, Pradillo JM, Perez de la Ossa N, Moro MA, Dávalos A, Lizasoain I. Iron overload, measured as serum ferritin, increases brain damage induced by focal ischemia and early reperfusion. Neurochem Int. 2012 Dec;61(8):1364-9. doi: 10.1016/j.neuint.2012.09.014
NO Instituto de Salud Carlos III
NO European Commission
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 21 abr 2025