RT Journal Article
T1 Association of Prolactin, Oxytocin, and Homocysteine With the Clinical and Cognitive Features of a First Episode of Psychosis Over a 1-Year Follow-Up
A1 Hidalgo Figueroa, María
A1 García Bueno, Borja
A1 Rodríguez Jiménez, Roberto
A1 Leza Cerro, Juan Carlos
AB BackgroundThe clinical debut of schizophrenia is frequently a first episode of psychosis (FEP). As such, there is considerable interest in identifying associations between biological markers and clinical or cognitive characteristics that help predict the progression and outcome of FEP patients. Previous studies showed that high prolactin, low oxytocin, and high homocysteine are factors associated with FEP 6 months after diagnosis, at which point plasma levels were correlated with some clinical and cognitive characteristics.MethodsWe reexamined 75 patients at 12 months after diagnosis to measure the evolution of these molecules and assess their association with clinical features.ResultsAt follow-up, FEP patients had lower prolactin levels than at baseline, and patients treated with risperidone or paliperidone had higher prolactin levels than patients who received other antipsychotic agents. By contrast, no changes in oxytocin and homocysteine plasma levels were observed between the baseline and follow-up. In terms of clinical features, we found that plasma prolactin and homocysteine levels were correlated with the severity of the psychotic symptoms in male FEP patients, suggesting that they might be factors associated with psychotic symptomatology but only in men. Together with oxytocin, these molecules may also be related to sustained attention, verbal ability, and working memory cognitive domains in FEP patients.ConclusionThis study suggests that focusing on prolactin, oxytocin, and homocysteine at a FEP may help select adequate pharmacological treatments and develop new tools to improve the outcome of these patients, where sex should also be borne in mind.
PB Oxford University Press
SN 1469-5111
YR 2023
FD 2023-08-21
LK https://hdl.handle.net/20.500.14352/134250
UL https://hdl.handle.net/20.500.14352/134250
LA eng
NO Maria Hidalgo-Figueroa, Alejandro Salazar, Cristina Romero-López-Alberca, Karina S MacDowell, Borja García-Bueno, Miquel Bioque, Miquel Bernardo, Mara Parellada, Ana González-Pinto, M Paz García-Portilla, Antonio Lobo, Roberto Rodriguez-Jimenez, Esther Berrocoso, Juan C Leza, FLAMM-PEPs study, CIBERSAM, Association of Prolactin, Oxytocin, and Homocysteine With the Clinical and Cognitive Features of a First Episode of Psychosis Over a 1-Year Follow-Up, International Journal of Neuropsychopharmacology, Volume 26, Issue 11, November 2023, Pages 796–807, https://doi.org/10.1093/ijnp/pyad051
NO CIBERSAM
NO Ministerio de Economía y Competitividad (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 8 abr 2026