RT Journal Article
T1 Obesity and telomere status in the prognosis of patients with colorectal cancer submitted to curative intention surgical treatment
A1 García Martínez, Sergio
A1 González Gamo, Daniel
A1 Fernández Marcelo, Tamara
A1 Tesolato, Sofía
A1 De La-Serna Esteban, Sofía Cristina
A1 Domínguez Serrano, María Inmaculada
A1 Cano Valderrama, Óscar
A1 Barabash Bustelo, Ana
A1 Juan Chocano, María Del Carmen De
A1 Torres García, Antonio José
A1 Iniesta Serrano, María Pilar
AB The risk of colorectal cancer (CRC) development has been associated with telomere dysfunction and obesity. However, clinical relevance of these parameters in CRC prognosis is not clear. Therefore, the aim of the present study was to evaluate the impact of obesity and telomere status in the prognosis of patients affected by CRC and submitted to curative surgical treatment. According to published data, this is the first work in which obesity and telomere status are jointly considered in relation to CRC prognosis. A prospective study including 162 patients with CRC submitted to curative surgical treatment was performed. Subjects were classified according to their BMI. Telomere status was established through telomere length and telomerase activity evaluation. Statistical analyses were performed using the SPSS software package version 22. Telomere shortening was inversely associated with BMI in patients with CRC. Notably, among patients with CRC, subjects with obesity exhibited less shortening of tumor telomeres than non‑obese patients (P=0.047). Patients with shorter telomeres, both in the tumor (median telomere length <6.5 kb) and their non‑tumor paired tissues (median telomere length <7.1 kb), had the best clinical evolution, regardless of the Dukes' stage of cancers (P=0.025, for tumor samples; P=0.003, for non‑tumor samples). Additionally, subjects with a BMI >31.85 kg/m2 showed the worse clinical outcomes compared with subjects with other BMI values. Interestingly, the impact of BMI showed sex dependence, since only the group of men displayed significant differences in CRC prognosis in relation to obesity status (P=0.037). From the results of the present study, based on a multivariate prediction model to establish prognosis, it was concluded that telomere length is a useful biomarker to predict prognosis in patients with CRC. Regardless of BMI values, the improved clinical evolution was associated with shorter telomeres. The impact of BMI seems to be associated with other factors, such as sex.
PB Spandidos Publications
SN 2049-9450
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/91601
UL https://hdl.handle.net/20.500.14352/91601
LA eng
NO García-Martínez S, González-Gamo D, Fernández-Marcelo T, Tesolato S, De la Serna S, Domínguez-Serrano I, Cano-Valderrama O, Barabash A, De Juan C, Torres-García A, Iniesta P. Obesity and telomere status in the prognosis of patients with colorectal cancer submitted to curative intention surgical treatment. Mol Clin Oncol. 2021, 15(3):184. doi: 10.3892/mco.2021.2346.
NO Instituto Carlos III
NO European Commission
DS Docta Complutense
RD 20 jul 2024