RT Journal Article
T1 Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease
A1 Infante-Menéndez, Jorge
A1 González-López, Paula
A1 Huertas-Lárez, Raquel
A1 Gómez Hernández, María De La Almudena
A1 Escribano Illanes, Óscar
AB Atherosclerosis and non-alcoholic fatty liver disease (NAFLD) are pathologies related to ectopic fat accumulation, both of which are continuously increasing in prevalence. These threats are prompting researchers to develop effective therapies for their clinical management. One of the common pathophysiological alterations that underlies both diseases is oxidative stress (OxS), which appears as a result of lipid deposition in affected tissues. However, the molecular mechanisms that lead to OxS generation are different in each disease. Non-coding RNAs (ncRNAs) are RNA transcripts that do not encode proteins and function by regulating gene expression. In recent years, the involvement of ncRNAs in OxS modulation has become more recognized. This review summarizes the most recent advances regarding ncRNA-mediated regulation of OxS in atherosclerosis and NAFLD. In both diseases, ncRNAs can exert pro-oxidant or antioxidant functions by regulating gene targets and even other ncRNAs, positioning them as potential therapeutic targets. Interestingly, both diseases have common altered ncRNAs, suggesting that the same molecule can be targeted simultaneously when both diseases coexist. Finally, since some ncRNAs have already been used as therapeutic agents, their roles as potential drugs for the clinical management of atherosclerosis and NAFLD are analyzed.
PB MDPI
SN 2076-3921
YR 2023
FD 2023-01-24
LK https://hdl.handle.net/20.500.14352/105196
UL https://hdl.handle.net/20.500.14352/105196
LA eng
NO Infante-Menéndez, J.; González-López, P.; Huertas-Lárez, R.; Gómez-Hernández, A.; Escribano, Ó. Oxidative Stress Modulation by ncRNAs and Their Emerging Role as Therapeutic Targets in Atherosclerosis and Non-Alcoholic Fatty Liver Disease. Antioxidants 2023, 12, 262. https://doi.org/10.3390/antiox12020262
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 6 abr 2025