RT Book, Section
T1 Klotho Prevents Translocation of NFκB
A1 Buendía, P.
A1 Ramírez, R.
A1 Aljama, P.
A1 Carracedo Añón, Julia María
A2 Litwack, Gerald
AB Klotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating form. This protein is recognized as an antiaging gene with pleiotropic functions. The activation of cellular systems is associated with the pathogenesis of several chronic and degenerative diseases associated with an inflammatory state. Inflammation is characterized by an activation of NFκB. Klotho suppresses nuclear factor NFκB activation and the subsequent transcription of proinflammatory genes. This review focuses on the current understanding of Klotho protein function and its relationship with NFκB regulation, emphasizing its potential involvement in the pathophysiologic process.
PB Elsevier
SN 9780128048191
SN 0083-6729
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/131839
UL https://hdl.handle.net/20.500.14352/131839
LA eng
NO Buendía, P., Ramírez, R., Aljama, P., & Carracedo, J. (2016). Klotho prevents translocation of nfκb. En Vitamins & Hormones (Vol. 101, pp. 119-150). Elsevier. https://doi.org/10.1016/bs.vh.2016.02.005
NO This work was supported by Plan Nacional de I+D+i Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII)-Subdirección General de Evaluación, Fondos de desarrollo regional (FEDER) (PI12/01489 and PI14/00806); Junta de Andalucía Grants (P010-CTS-6337, P11-CTS-7352); and Fundación Nefrológica. J.C. was supported by a contract from Fundación de Investigaciones Biomédicas de Córdoba (Servicio Andaluz de Salud, Programa Nicolás Monardes). P.B. is fellow from Consejería de...
NO Instituto de Salud Carlos III
NO Junta de Andalucía
NO Fundación Nefrológica
NO Fundación de Investigaciones Biomédicas de Córdoba
DS Docta Complutense
RD 21 mar 2026