RT Journal Article
T1 Value of NT-proBNP and Galectin-3 as Biomarkers in the Follow-Up of Asymptomatic Elderly Patients with Severe Aortic Stenosis
A1 Ramos, Mónica
A1 Quezada-Feijoó, Maribel
A1 Ayala, Rocío
A1 Manzano, Ascensión
A1 Gómez-Pavón, Francisco
A1 Jaramillo, Javier
A1 Herrera, Cristina
A1 López Vazquez de la Torre, Mariola
A1 Toro, Rocío
AB Recognizing symptoms in elderly patients with severe aortic stenosis (AS) can be a challenge. Serum biomarkers such as Galectin-3 or N-terminal prohormone B-type natriuretic peptide (NT-proBNP) are involved in remodeling and heart failure (HF) development and could support the diagnosis of AS. We set out to test the usefulness of NT-proBNP and Galectin-3 in predicting events in this population. We designed a prospective observational case–control study, including 50 asymptomatic patients older than 70 years, diagnosed with severe degenerative AS, and 50 control individuals. The NT-proBNP and Galectin-3 levels were measured. A follow-up was carried out at 12 months to determine the occurrence of hospital admission for HF, all-cause mortality or the appearance of symptoms. The patients with severe AS had higher Galectin-3 and NT-proBNP concentrations. The area under the receiver operating characteristic curve of the NT-proBNP was 0.812 (95% CI, 0.646–0.832), and that of the Galectin-3 was 0.633 (95% CI, 0.711–0.913). NT-proBNP was a good predictor of events [HR 3.45 (95% CI 1.32–9.03), p = 0.011]. A Kaplan–Meier analysis showed that the probability of freedom from events was significant in patients who exhibited a combination of higher NT-proBNP and Galectin-3 levels (log-rank p = 0.032). Therefore, NT-proBNP was the most reliable predictor of events in asymptomatic patients with severe AS. A combination of NT-proBNP and Galectin-3 levels may be vital in the clinical follow-up of these patients and in the decision-making process.
PB MPDI
YR 2023
FD 2023-04-20
LK https://hdl.handle.net/20.500.14352/103643
UL https://hdl.handle.net/20.500.14352/103643
LA eng
NO Ramos, M.; Quezada-Feijoó, M.; Ayala, R.; Manzano, A.; Gómez-Pavón, F.J.; Jaramillo, J.; Herrera, C.; López Vazquez de la Torre, M.; Toro, R. Value of NT-proBNP and Galectin-3 as Biomarkers in the Follow-Up of Asymptomatic Elderly Patients with Severe Aortic Stenosis. J. Clin. Med. 2023, 12, 2987. https://doi.org/10.3390/jcm12082987
NO Banco Santander (España)
NO Universidad Alfonso X el Sabio
NO Sociedad Española de Investigación
NO European Commission
DS Docta Complutense
RD 23 abr 2025