RT Journal Article
T1 Risk of incident dementia in drug-untreated arterial hypertension: a population-based study
A1 Bermejo Pareja, Félix
A1 Benito León, Julián
A1 Louis, Elan D.
A1 Trincado, Rocío
A1 Carro, Eva
A1 Villarejo Galende, Alberto
A1 Gómez De La Cámara, Agustín Ramón
AB Arterial hypertension in midlife may increase the risk of late-life dementia. Notably, there is conflicting data as to whether hypertension in the elderly (age 65 years and older) is a risk factor for dementia and Alzheimer's disease (AD). We determined whether drug-untreated hypertension was associated with a higher risk of incident dementia and AD. In a population-based study of older people in central Spain (NEDICES), non-demented participants were followed prospectively. Dementia at follow-up was diagnosed using DSM-IV criteria. Using Cox proportional hazards models, the risk of dementia was estimated in participants with drug-untreated hypertension and in participants with drug-treated hypertension versus controls. The 3,824 participants had a mean duration of follow-up of 3.2 years. Sixty-two (3.3%) of 1,870 participants without baseline hypertension developed incident dementia versus 78 (4.7%) of 1,657 with drug-treated, baseline hypertension and 19 (12.0%) with drug-untreated, baseline hypertension. In an unadjusted Cox model, risk of dementia was increased in participants with drug-untreated hypertension (relative risk [RR] =1.93, 95% confidence interval [CI]=1.15–3.23, p = 0.01) and in participants with drug-treated hypertension (RR =1.43, 95% CI= 1.02–2.0, p =0.035) versus participants without hypertension (reference group). In a fully adjusted Cox model, the risk of dementia remained increased in participants with drug-untreated hypertension (RR =2.38, 95% CI =1.32–4.29, p=0.004). Results were similar for risk of AD. Our results suggest that drug-untreated hypertension may be an independent risk factor for dementia and AD in the elderly.
PB SAGE Publications
SN 1387-2877
YR 2010
FD 2010-11-25
LK https://hdl.handle.net/20.500.14352/117574
UL https://hdl.handle.net/20.500.14352/117574
LA eng
NO 1. Bermejo-Pareja F, Benito-León J, Louis ED, et al. Risk of Incident Dementia in Drug-Untreated Arterial Hypertension: A Population-Based Study. Journal of Alzheimer’s Disease. 2010;22(3):949-958. doi:10.3233/JAD-2010-101110
DS Docta Complutense
RD 8 abr 2025