RT Journal Article T1 Biocatalytic production of biolubricants: strategies, problems and future trends A1 Monteiro, Rodolpho R.C. A1 Berenguer Murcia, Ángel A1 Rocha Martín, Javier A1 Vieira, Rodrigo S. A1 Fernandez Lafuente, Roberto AB The increasing worries by the inadequate use of energy and the preservation of nature are promoting an increasing interest in the production of biolubricants. After discussing the necessity of producing biolubricants, this review focuses on the production of these interesting molecules through the use of lipases, discussing the different possibilities (esterification of free fatty acids, hydroesterification or transesterification of oils and fats, transesterification of biodiesel with more adequate alcohols, estolides production, modification of fatty acids). The utilization of discarded substrates has special interest due to the double positive ecological impact (e.g., oil distillated, overused oils). Pros and cons of all these possibilities, together with general considerations to optimize the different processes will be outlined. Some possibilities to overcome some of the problems detected in the production of these interesting compounds will be also discussed. PB Elsevier SN 0734-9750 YR 2023 FD 2023-07 LK https://hdl.handle.net/20.500.14352/121670 UL https://hdl.handle.net/20.500.14352/121670 LA eng NO Monteiro RRC, Berenguer-Murcia Á, Rocha-Martin J, Vieira RS, Fernandez-Lafuente R. Biocatalytic production of biolubricants: Strategies, problems and future trends. Biotechnology Advances 2023;68:108215. https://doi.org/10.1016/j.biotechadv.2023.108215. NO Acknowledgements:We gratefully recognize the financial support from Ministerio de Ciencia e Innovación and Agencia Estatal de Investigación (Spanish Government) (PID2022-136535OB-I00 and TED2021-131462B-I00). R.R.C.M. thanks Programa de Formação de Recursos Humanos – Agência Nacional de Petróleo, Gás Natural e Biocombustíveis/Financiadora de Estudos e Projetos (PRH 31.1 – ANP/Finep). NO Ministerio de Ciencia e Innovación (España) NO Agencia Estatal de Investigación (España) NO Agência Nacional de Petróleo, Gás Natural e Biocombustíveis (Brasil) DS Docta Complutense RD 27 dic 2025