RT Journal Article
T1 When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration
A1 Michalska Dziama, Patrycja
A1 León Martínez, Rafael
AB Neurodegenerative diseases are characterized by a progressive loss of neurons in the brain or spinal cord that leads to a loss of function of the affected areas. The lack of effective treatments and the ever-increasing life expectancy is raising the number of individuals affected, having a tremendous social and economic impact. The brain is particularly vulnerable to oxidative damage given the high energy demand, low levels of antioxidant defenses, and high levels of metal ions. Driven by age-related changes, neurodegeneration is characterized by increased oxidative stress leading to irreversible neuronal damage, followed by cell death. Nevertheless, neurodegenerative diseases are known as complex pathologies where several mechanisms drive neuronal death. Herein we discuss the interplay among oxidative stress, proteinopathy, and neuroinflammation at the early stages of neurodegenerative diseases. Finally, we discuss the use of the Nrf2-ARE pathway as a potential therapeutic strategy based on these molecular mechanisms to develop transformative medicines.
PB MDPI
YR 2020
FD 2020-08-07
LK https://hdl.handle.net/20.500.14352/95948
UL https://hdl.handle.net/20.500.14352/95948
LA eng
NO Michalska P, León R. When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration. Antioxidants 2020;9:740. https://doi.org/10.3390/antiox9080740.
NO Instituto de Salud Carlos III
NO European Regional Development’s funds
NO Programa Miguel Servet II
NO Comunidad de Madrid
NO Federación Española de Enfermedades Raras
DS Docta Complutense
RD 23 ago 2024