TY  - JOUR
AU  - Więckowska, Anna
AU  - Szałaj, Natalia
AU  - Góral, Izabella
AU  - Bucki, Adam
AU  - Latacz, Gniewomir
AU  - Kiec Kononowicz, Katarzyna
AU  - Bautista Aguilera, Òscar M
AU  - Romero Martínez, Manuel Alejandro
AU  - Ramos Alonso, Eva
AU  - Egea, Javier
AU  - Farré Alíns, Victor
AU  - González Rodríguez, Águeda
AU  - López Muñoz, Francisco
AU  - Chioua, Mourad
AU  - Marco Contelles, José Luis
PY  - 2020
DO  - 10.1021/acschemneuro.0c00489
SN  - 1948-7193
UR  - https://hdl.handle.net/20.500.14352/120425
T2  - ACS Chemical Neuroscience
AB  - Herein we report  metabolic stability in human liver microsomes (HLMs), interactions with cytochrome P450 isoenzymes (CYP3A4, CYP2D6, and CYP2C9), and cytotoxicity analyses on HEK-293, HepG2, Huh7, and WTIIB cell lines of our most recent multitarget...
LA  - eng
M2  - 3793
PB  - ACS American Chemical Society
KW  - ADME-tox
KW  - ASS234
KW  - Alzheimer’s disease
KW  - Contilisant
KW  - Cytochrome P450 enzymes
KW  - Cytotoxicity
KW  - MAO inhibitors
KW  - Metabolism
KW  - Multitarget directed ligands
KW  - PF9601N
TI  - In Vitro and  In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases.
TY  - journal article
VL  - 11
ER  -