RT Journal Article
T1 Cidal activity of oral third-generation cephalosporins against Streptococcus pneumoniae in relation to cefotaxime intrinsic activity
A1 Cafini, Fabio
A1 Aguilar, Lorenzo
A1 Alou Cervera, Luis
A1 Giménez, María José
A1 Sevillano Fernández, David
A1 Torrico, Martha
A1 González Hidalgo, Natalia
A1 Granizo, Juan José
A1 Martín Herrero, José Emilio
A1 Prieto Prieto, José
AB This study explores the killing kinetics within 12 h of four oral third-generation cephalosporins against ten Streptococcus pneumoniae strains exhibiting cefotaxime minimum inhibitory concentrations (MICs) from 0.03 to 2 microg/ml. Killing curves were performed with concentrations achievable in serum after standard doses (0.015-4 microg/ml). Reductions of 90% were achieved with all compounds at serum-achievable concentrations for strains exhibiting cefotaxime MIC < or = 0.5 microg/ml. Against strains with cefotaxime MIC > or = 1 microg/ml, only cefditoren reached a 90% reduction with concentrations of 0.5-1 microg/ml doses. At 4 microg/ml, cefditoren and cefotaxime reached 99.9% reduction in seven of the ten strains studied. At serum-achievable concentrations, cefdinir and cefixime were not bactericidal against strains exhibiting cefotaxime MIC > or = 0.25 microg/ml and > or = 0.5 microg/ml, respectively. Cefditoren showed the best killing kinetic profiles and this observation may be important when choosing an oral third-generation cephalosporin as initial or sequential therapy
PB Springer
SN 0934-9723
YR 2008
FD 2008-02-26
LK https://hdl.handle.net/20.500.14352/107149
UL https://hdl.handle.net/20.500.14352/107149
LA eng
NO Cafini F, Aguilar L, Alou L, Giménez MJ, Sevillano D, Torrico M, González N, Granizo JJ, Martín-Herrero JE, Prieto J. Cidal activity of oral third-generation cephalosporins against Streptococcus pneumoniae in relation to cefotaxime intrinsic activity. Eur J Clin Microbiol Infect Dis. 2008 Aug;27(8):679-83.
NO GlaxoSmithKline S.A.
DS Docta Complutense
RD 23 abr 2025