RT Journal Article
T1 Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived severe acute respiratory syndrome coronavirus 2 infection: a systematic review and meta-analysis
A1 Fernández de las Peñas, César
A1 Navarro Santana, Marcos José
A1 Plaza Manzano, Gustavo
A1 Palacios Ceña, Domingo
A1 Arendt Nielsen, Lars
A2 International Association for the Study of Pain, 
AB The aim of this review or meta-analysis is to synthesize the prevalence of post-coronavirus disease (COVID) pain symptoms of musculoskeletal origin in hospitalized or nonhospitalized patients recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. MEDLINE, CINAHL, PubMed, EMBASE, and Web of Science databases, as well as medRxiv and bioRxiv preprint servers were searched up to May 1, 2021. Studies or preprints reporting data on post-COVID pain symptoms such as myalgias, arthralgias, or chest pain after SARS-CoV-2 infection and collected by personal, telephonic, or electronical interview were included. The methodological quality of the studies was assessed using the Newcastle–Ottawa Scale. Random-effects models were used for meta-analytical pooled prevalence of each post-COVID musculoskeletal pain symptom. Data synthesis was categorized at onset or hospital admission and at 30, 60, and 90, and ≥180 days after. From a total of 12,123 studies identified, 27 peer-reviewed studies and 6 preprints were included. The sample included 14,639 hospitalized and 11,070 nonhospitalized COVID-19 patients. The methodological quality of almost 70% studies was fair. The overall prevalence of post-COVID myalgia, joint pain, and chest pain ranged from 5.65% to 18.15%, 4.6% to 12.1%, and 7.8% to 23.6%, respectively, at different follow-up periods during the first year postinfection. Time trend analysis showed a decrease prevalence of musculoskeletal post-COVID pain from the symptom's onset to 30 days after, an increase 60 days after, but with a second decrease ≥180 days after. This meta-analysis has shown that almost 10% of individuals infected by SARS-CoV-2 will suffer from musculoskeletal post-COVID pain symptomatology at some time during the first year after the infection.
PB Elsevier
SN 0304-3959
SN 1872-6623
YR 2021
FD 2021-09-23
LK https://hdl.handle.net/20.500.14352/104805
UL https://hdl.handle.net/20.500.14352/104805
LA eng
NO Fernández-de-las-Peñas, Césara,b,*; Navarro-Santana, Marcosc; Plaza-Manzano, Gustavoc,d; Palacios-Ceña, Domingoa; Arendt-Nielsen, Larsb. Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived severe acute respiratory syndrome coronavirus 2 infection: a systematic review and meta-analysis. PAIN 163(7):p 1220-1231, July 2022. | DOI: 10.1097/j.pain.0000000000002496
DS Docta Complutense
RD 31 dic 2025