RT Journal Article T1 The Impact of the Drying Process on the Antioxidant and Anti-Inflammatory Potential of Dried Ripe Coffee Cherry Pulp Soluble Powder A1 López Parra, Marta B. A1 Gómez Domínguez, Irene A1 Iriondo De Hond, Maite A1 Villamediana Merino, Esther A1 Sánchez Martín, Vanesa A1 Mendiola, José A. A1 Iriondo De Hond, Amaia A1 Del Castillo, María Dolores AB Coffee fruit cascara, which is the skin and pulp of the coffee cherry, has been authorized as a novel food for commercialization in the European Union. The present research assessed the feasibility of using spray drying to produce a soluble powder called instant cascara (IC), employing sun-dried ripe coffee cherry pulp as a raw material. Although there were no significant differences (p > 0.05) in the overall antioxidant capacity between the freeze-dried and spray-dried samples, after an in vitro simulation of the digestion process, the spray-dried sample was significantly (p < 0.05) more antioxidant. Both samples reduced physiological intracellular ROS and significantly decreased (p < 0.05) the secretion of the pro-inflammatory factor NO. Alkaloids and phenolic compounds were detected in intestinal digests. In conclusion, spray drying is a good technique for producing IC as its use does not affect its properties and causes less environmental impact than freeze drying, as calculated by life cycle assessment. Sensory analysis did not show significant differences between the commercial beverage and the IC beverage in the adult population. IC at 10 mg/mL was significantly less accepted in adolescents than the commercial beverage. Future work will include the reformulation of the IC beverage at 10 mg/mL, which has antioxidant and anti-inflammatory potential, to increase its hedonic acceptance in all consumer segments. PB MDPI SN 2304-8158 YR 2024 FD 2024-04-05 LK https://hdl.handle.net/20.500.14352/103318 UL https://hdl.handle.net/20.500.14352/103318 LA eng NO López-Parra, M.B.; Gómez-Domínguez, I.; IriondoDeHond, M.; Villamediana Merino, E.; Sánchez-Martín, V.; Mendiola, J.A.; Iriondo-DeHond, A.; del Castillo, M.D. The Impact of the Drying Process on the Antioxidant and Anti-Inflammatory Potential of Dried Ripe Coffee Cherry Pulp Soluble Powder. Foods 2024, 13, 1114. https:// doi.org/10.3390/foods13071114 NO Author Contributions: Conceptualization, M.D.d.C.; methodology, J.A.M., E.V.M., A.I.-D. and M.D.d.C.; formal analysis, M.B.L.-P., I.G.-D., M.I.-D., V.S.-M., J.A.M. and E.V.M.; investigation, M.I.-D., V.S.-M., J.A.M., A.I.-D. and M.D.d.C.; data curation, M.B.L.-P., I.G.-D., M.I.-D., V.S.-M., J.A.M. and E.V.M.; writing—original draft preparation, M.B.L.-P. and M.D.d.C.; writing—review and editing, M.B.L.-P., I.G.-D., M.I.-D., V.S.-M., J.A.M., E.V.M., A.I.-D. and M.D.d.C.; supervision, M.D.d.C.; projectadministration, M.D.d.C.; funding acquisition, M.D.d.C. All authors have read and agreed to the published version of the manuscript. NO Ministerio de Ciencia e Innovación DS Docta Complutense RD 2 sept 2024