RT Journal Article
T1 African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa
A1 Berg, Stefan
A1 García Pelayo, M Carmen
A1 Müller, Borna
A1 Hailu, Elena
A1 Asiimwe, Benon
A1 Kremer, Kristin
A1 Dale, James
A1 Boniotti, M Beatrice
A1 Rodriguez, Sabrina
A1 Hilty, Markus
A1 Rigouts, Leen
A1 Firdessa, Rebuma
A1 Machado, Adelina
A1 Mucavele, Custodia
A1 Ngandolo, Bongo Nare Richard
A1 Bruchfeld, Judith
A1 Boschiroli, Laura
A1 Müller, Annélle
A1 Sahraoui, Naima
A1 Pacciarini, Maria
A1 Cadmus, Simeon
A1 Joloba, Moses
A1 van Soolingen, Dick
A1 Michel, Anita L
A1 Djønne, Berit
A1 Aranaz Martín, Alicia
A1 Zinsstag, Jakob
A1 van Helden, Paul
A1 Portaels, Françoise
A1 Kazwala, Rudovick
A1 Källenius, Gunilla
A1 Hewinson, R Glyn
A1 Aseffa, Abraham
A1 Gordon, Stephen V
A1 Smith, Noel H
AB We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. We have named this related group of M. bovis strains the African 2 (Af2) clonal complex of M. bovis. Af2 strains are defined by a specific chromosomal deletion (RDAf2) and can be identified by the absence of spacers 3 to 7 in their spoligotype patterns. Deletion analysis of M. bovis isolates from Algeria, Mali, Chad, Nigeria, Cameroon, South Africa, and Mozambique did not identify any strains of the Af2 clonal complex, suggesting that this clonal complex of M. bovis is localized in East Africa. The specific spoligotype pattern of the Af2 clonal complex was rarely identified among isolates from outside Africa, and the few isolates that were found and tested were intact at the RDAf2 locus. We conclude that the Af2 clonal complex is localized to cattle in East Africa. We found that strains of the Af2 clonal complex of M. bovis have, in general, four or more copies of the insertion sequence IS6110, in contrast to the majority of M. bovis strains isolated from cattle, which are thought to carry only one or a few copies.
PB American Society for Microbiology
SN 1098-5530
YR 2011
FD 2011-02
LK https://hdl.handle.net/20.500.14352/45185
UL https://hdl.handle.net/20.500.14352/45185
LA eng
DS Docta Complutense
RD 30 abr 2024