RT Journal Article
T1 Ontogeny of Sex-Related Differences in Foetal Developmental Features, Lipid Availability and Fatty Acid Composition
A1 Garcia-Contreras, Consolacion
A1 Vázquez Gómez, Marta
A1 Astiz, Susana
A1 Torres-Rovira, Laura
A1 Sanchez-Sanchez, Raul
A1 Gomez-Fidalgo, Ernesto
A1 Gonzalez, Jorge
A1 Isabel Redondo, Beatriz
A1 Rey Muñoz, Ana Isabel
A1 Ovilo, Cristina
A1 González Bulnes, Antonio
AB Sex-related differences in lipid availability and fatty acid composition during swine foetal development were investigated. Plasma cholesterol and triglyceride concentrations in the mother were strongly related to the adequacy or inadequacy of foetal development and concomitant activation of protective growth in some organs (brain, heart, liver and spleen). Cholesterol and triglyceride availability was similar in male and female offspring, but female foetuses showed evidence of higher placental transfer of essential fatty acids and synthesis of non-essential fatty acids in muscle and liver. These sex-related differences affected primarily the neutral lipid fraction (triglycerides), which may lead to sex-related postnatal differences in energy partitioning. These results illustrate the strong influence of the maternal lipid profile on foetal development and homeorhesis, and they confirm and extend previous reports that female offspring show better adaptive responses to maternal malnutrition than male offspring. These findings may help guide dietary interventions to ensure adequate fatty acid availability for postnatal development.
PB MDPI
SN 1422-0067
YR 2017
FD 2017-05-31
LK https://hdl.handle.net/20.500.14352/19144
UL https://hdl.handle.net/20.500.14352/19144
LA eng
NO Ministerio de Economía y Competitividad de España (MINECO)/FEDER
NO Unión Europea/Cooperación Europea en Ciencia y Tecnología (COST)
DS Docta Complutense
RD 29 abr 2024