%0 Journal Article
%A García Silva, Susana
%A Benito Martín, Alberto
%A Sánchez Redondo, Sara
%A Hernández Barranco, Alberto
%A Ximénez Embún, Pilar
%A Nogues Vera, Laura
%A Mazariegos, Marina S.
%A Brinkmann, Kay
%A Amor López, Ana
%A Meyer, Lisa
%A Rodríguez, Carlos
%A García Martín, Carmen
%A Boskovic, Jasminka
%A Letón, Rocío
%A Montero, Cristina
%A Robledo, Mercedes
%A Santambrogio, Laura
%A Sue Brady, Mary
%A Szumera Ciećkiewicz, Anna
%A Kalinowska, Iwona
%A Skog, Johan
%A Noerholm, Mikkel
%A Muñoz, Javier
%A Ortiz Romero, Pablo Luis
%A Ruano, Yolanda
%A Rodríguez Peralto, José Luis
%A Rutkowski, Piotr
%A Peinado, Héctor
%T Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation
%D 2019
%@ 0022-1007
%@ 1540-9538
%U https://hdl.handle.net/20.500.14352/131088
%X Liquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogatemarkers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting.Wehave characterized extracellular vesicles purified from the lymphatic drainage also known as exudative seroma (ES) of stageIII melanoma patients obtained after lymphadenectomy. Proteomic analysis showed that seroma-derived exosomes areenriched in proteins resembling melanoma progression. In addition, we found that the BRAFV600E mutation can be detected inES-derived extracellular vesicles and its detection correlated with patients at risk of relapse.
%~