%0 Journal Article
%A De Egea, V.
%A Guembe, M.
%A Rodríguez-Borlado, A.
%A Pérez Granda, María Jesús
%A Sánchez-Carrillo, C.
%A Bouza Santiago, Emilio
%T Should non-bacteraemic patients with a colonized catheter receive antimicrobial therapy?
%D 2017
%@ 1201-9712
%@ 1878-3511
%U https://hdl.handle.net/20.500.14352/120346
%X ObjectivesThe impact of antimicrobial therapy on the outcomes of patients with colonized catheters and no bacteraemia has not been assessed. This study assessed whether targeted antibiotic therapy is related to a poor outcome in patients with positive cultures of blood drawn through a non-tunnelled central venous catheter (CVC) and without concomitant bacteraemia.MethodsThis was a retrospective study involving adult patients with positive blood cultures drawn through a CVC and negative peripheral vein blood cultures. Patients were classified into two groups: those with clinical improvement and those with a poor outcome. These two groups were compared. The outcome was considered poor in the presence of one or more of the following: death, bacteraemia or other infection due to the same microorganism, and evidence of catheter-related bloodstream infection.ResultsA total of 100 patients were included (31 with a poor outcome). The only independent predictors of a poor outcome were a McCabe and Jackson score of 1–2 and a median APACHE score of 5. No association was found between the use of targeted antimicrobial therapy and a poor outcome when its effect was adjusted for the rest of the variables.ConclusionsThis study showed that antimicrobial therapy was not associated with a poor outcome in non-bacteraemic patients with positive blood cultures drawn through a CVC.
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