RT Journal Article
T1 Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Prenatal Effects on Growth and Metabolism
A1 De las Heras Molina, Ana
A1 Pesántez Pacheco, José Luis
A1 García Contreras, Consolación
A1 Vázquez Gómez, Marta
A1 López, Adrián
A1 Benítez, Rita
A1 Núñez, Yolanda
A1 Astiz, Susana
A1 Óvilo, Cristina
A1 Isabel Redondo, Beatriz
A1 González Bulnes, Antonio
A2 MDPI, 
AB Maternal supplementation with antioxidants and n-3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-neonates. A previous studies showed beneficial outcomes of the combination of hydroxytyrosol and linoleic acid, but there is no data of its prenatal effects. The present study aimed to determine the possible prenatal implications of such maternal supplementation at prenatal stages in swine, a model of IUGR pregnancies. Results showed effects on litter size, with treated shows having larger litters and, therefore, smaller fetuses. However, the brain/head weight ratio showed a positive effect of the treatment in development, as well as in some other major organs like lungs, spleen, or kidneys. On the other hand, treated piglets showed better glycemic and lipidemic profiles, which could explain postnatal effects. However, further research on the implications of the treatment on litter size and prenatal and postnatal development must be done before practical recommendation can be given.
PB MDPI
YR 2021
FD 2021-06
LK https://hdl.handle.net/20.500.14352/93730
UL https://hdl.handle.net/20.500.14352/93730
LA eng
NO Heras-Molina, Ana, José Luis Pesántez-Pacheco, Consolación Garcia-Contreras, Marta Vázquez-Gómez, Adrián López, Rita Benítez, Yolanda Núñez, et al. «Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Prenatal Effects on Growth and Metabolism». Animals 11, n.o 6 (7 de junio de 2021): 1699. https://doi.org/10.3390/ani11061699.
NO The present study aimed to determine benefits and risks of a dietary supplementation combining hydroxytyrosol and n-3 polyunsaturated fatty acids (PUFA) on prenatal development and metabolic traits in swine, a model of intrauterine growth restricted (IUGR) pregnancies. No effects were found regarding sows’ weight and adiposity. Treated sows had larger litters, with smaller fetuses. However, these animals had better development of some major organs. Fetuses from the treated group had better glycemic and lipidic indexes, but no effects on anti/prooxidant profiles were found.
NO Ministry of Economy and Competitiveness (project AGL2016-79321-C2-2-R and AGL2019-108695RB-C31), co-funded by FEDER.
NO AHM, CGC and MVG were supported by the Spanish Government (AHM: FPI National Program BES-2017-080541; CGC: FPI BES-2014-070464; MVG: FPU National Program FPU014/01285).
DS Docta Complutense
RD 12 abr 2025