RT Journal Article
T1 Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors
A1 López Cuenca, Inés
A1 García Martín, Elena Salobrar
A1 Sánchez-Puebla Fernández, Lidia
A1 Espejel Checa, Eva
A1 García del Arco, Lucía
A1 Rojas Lozano, María Del Pilar
A1 Elvira Hurtado, Lorena
A1 Fernández Albarral, José
A1 Ramírez Toraño, Federico
A1 Barabash Bustelo, Ana
A1 Salazar Corral, Juan José
A1 Ramírez Sebastián, José Manuel
A1 Hoz Montañana, María Rosa De
A1 Ramírez Sebastián, Ana Isabel
AB In 103 subjects with a high genetic risk of developing Alzheimer’s disease (AD), family history (FH) of AD and ApoE ɛ4 characterization (ApoE ɛ4) were analyzed for changes in the retinal vascular network by OCTA (optical coherence tomography angiography), and AngioTool and Erlangen-Angio-Tool (EA-Tool) as imaging analysis software. Retinal vascularization was analyzed by measuring hypercholesterolemia (HCL) and high blood pressure (HBP). Angio-Tool showed a statistically significant higher percentage of area occupied by vessels in the FH+ ApoE ɛ4- group vs. in the FH+ ApoE ɛ4+ group, and EA-Tool showed statistically significant higher vascular densities in the C3 ring in the FH+ ApoE ɛ4+ group when compared with: i)FH- ApoE ɛ4- in sectors H3, H4, H10 and H11; and ii) FH+ ApoE ɛ4- in sectors H4 and H12. In participants with HCL and HBP, statistically significant changes were found, in particular using EA-Tool, both in the macular area, mainly in the deep plexus, and in the peripapillary area. In conclusion, OCTA in subjects with genetic risk factors for the development of AD showed an apparent increase in vascular density in some sectors of the retina, which was one of the first vascular changes detectable. These changes constitute a promising biomarker for monitoring the progression of pathological neuronal degeneration.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-06-06
LK https://hdl.handle.net/20.500.14352/71692
UL https://hdl.handle.net/20.500.14352/71692
LA eng
NO López Cuenca, I., García Martín, E. S., Sánchez-Puebla Fernández, L. et al. «Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors». Journal of Clinical Medicine, vol. 11, n.o 11, junio de 2022, p. 3248. DOI.org (Crossref), https://doi.org/10.3390/jcm11113248.
NO This article belongs to the Special Issue Predicting the Evolution of Neurological Diseases: The Role of Biomarkers in 2022 and Beyond
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Ministerio de Economía, Comercio y Empresa (España)
NO Instituto de Salud Carlos III
NO Universidad Complutense de Madrid
NO Ministerio de Educación, Formación Profesional y Deportes (España)
DS Docta Complutense
RD 8 abr 2025