RT Journal Article
T1 Novel Multitarget Hybrid Compounds for the Treatment of Alzheimer’s Disease
A1 Michalska Dziama, Patrycja
A1 Buendia, Izaskun
A1 Almale Del Barrio, Laura
A1 León Martínez, Rafael
AB Alzheimer's disease (AD) is the most prevalent among the aging diseases known as neurodegenerative disorders. Drug design programs over the last two decades were mainly based on the cholinergic, the amyloid or the tau hypothesis. However, none of the new drugs have a real impact on the outcome of the disease. The complex nature of AD has led to new approaches for drug development programs, the multitarget drug design hypothesis. Based on this hypothesis, the generation of multitarget hybrid compounds from previously known active molecules has been one of the most widely used to obtain new candidates for the future treatment of AD. Here, we summarize recent developments based on the hybridization hypothesis to obtain a potential clinical candidate for AD.
SN 1568-0266
YR 2016
FD 2016-06-19
LK https://hdl.handle.net/20.500.14352/97112
UL https://hdl.handle.net/20.500.14352/97112
LA eng
NO Comisión Europea
NO Ministerio de Sanidad(España)
NO Instituto de Salud Carlos III
NO Fundación FIPSE
NO Ministerio de Educación, Cultura y Deporte(España)
NO Miguel Servet
DS Docta Complutense
RD 23 ago 2024