RT Conference Proceedings
T1 The light damage could be to reduce with a blue filters without affected to functionality of photosensitive ganglion cells.
T2 El daño lumínico podría reducirse con filtros azules sin afectar a la funcionalidad de las células ganglionares fotosensibles.
A1 Vicente Tejedor, J.
A1 Ramírez, L.
A1 García Ortega, M.
A1 Bonnin Arias, Cristina Natalia
A1 Marchena, M.
A1 Navarro, J.
A1 Ramírez, G.
A1 Lobato Rincón, Luis Lucio
A1 De la Villa, P.
A1 Sánchez Ramos, Celia
AB PURPOSE:  Blue light has been shown to induce a retinal damage in retina which determines significant decrease of retinal light responses. Nevertheless, maximum sensitivity of intrinsically photosensitive ganglion cells (ipRGCs) also range in the blue spectrum. We have tested the protective effect of light filters in the 400-500 wavelength range on light sensivity and also we have observed if blue filters may also affect the circadian activity.METHODS: Light damage was induced in experimental mice by the use of 7 days of continuous white light of high intensity (5000 lux). Flash electroretinogram responses were recorded under light and dark adaptation in all. Similar experiments were performed in a second series of animals after filtering the damaging light with sort wavelength light filters. Circadian Activity of albino and pigmented mice were tested by the use of wheel activity cages. In a final series of experiments, we employed the circadian activity in Rd10 mice.
YR 2011
FD 2011-11-05
LK https://hdl.handle.net/20.500.14352/108956
UL https://hdl.handle.net/20.500.14352/108956
LA eng
DS Docta Complutense
RD 6 abr 2025