RT Journal Article
T1 Lactase persistence, NOD2 status and Mycobacterium avium subsp. paratuberculosis infection associations to Inflammatory Bowel Disease
A1 Elguezabal, Natalia
A1 Chamorro Francisco, Susana
A1 Molina, Elena
A1 Garrido, Joseba
A1 Izeta, Ander
A1 Rodrigo, Luis
A1 Juste, Ramón
AB Inflammatory Bowel Disease (IBD), which includes both Crohn’s disease (CD) and ulcerative colitis (UC), is caused by a complex interplay involving genetic predisposition, environmental factors and an infectious agent. Mycobacterium avium subsp. paratuberculosis (MAP) is a promising pathogen candidate since it produces a chronic intestinal inflammatory disease in ruminants that resembles CD in humans. MAP is a ubiquitous microorganism, although its presence in the food chain, especially in milk from infected animals, is what made us think that there could be an association between lactase persistence (LP) and IBD. The LCT mutation has brought adaptation to dairy farming which in turn would have increased exposure of the population to infection by MAP. NOD2 gene mutations are highly associated to CD.
PB Springer Nature
SN 1757-4749
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/97987
UL https://hdl.handle.net/20.500.14352/97987
LA eng
NO Elguezabal, N., Chamorro, S., Molina, E. et al. Lactase persistence, NOD2 status and Mycobacterium avium subsp. paratuberculosis infection associations to Inflammatory Bowel Disease. Gut Pathog 4, 6 (2012). https://doi.org/10.1186/1757-4749-4-6
NO Eusko Jaurlaritza
DS Docta Complutense
RD 17 abr 2025