RT Journal Article T1 Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004 A1 Rodríguez, Irene A1 Novais, Ângela A1 Lira, Felipe A1 Valverde, Aránzazu A1 Curião, Tânia A1 Martínez, José Luis A1 Baquero, Fernando A1 Cantón, Rafael A1 Coque, Teresa M AB We describe the genetic background of bla(TEM-4) and the complete sequence of pRYC11::bla(TEM-4), a mosaic plasmid that is highly similar to pKpQIL-like variants, predominant among TEM-4 producers in a Spanish hospital (1990 to 2004), which belong to Klebsiella pneumoniae and Escherichia coli high-risk clones responsible for the current spread of different antibiotic resistance genes. Predominant populations of plasmids and host adapted clonal lineages seem to have greatly contributed to the spread of resistance to extended-spectrum cephalosporins. PB American Society for Microbiology SN 1098-6596 YR 2015 FD 2015-05 LK https://hdl.handle.net/20.500.14352/24668 UL https://hdl.handle.net/20.500.14352/24668 LA eng NO Unión Europea. FP7 NO Instituto de Salud Carlos III DS Docta Complutense RD 1 may 2024