RT Journal Article
T1 Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against Candida spp. Biofilm Infections
A1 Benavent Núñez, Carlos
A1 Torrado Salmerón, Carlos Félix
A1 Torrado Durán, Santiago
AB The aim of this study was to improve the treatment of Candida albicans biofilms through the use of nystatin solid dispersions developed using maltodextrins as a hyperosmotic carrier. Characterization studies by differential scanning calorimetry, X-ray diffraction, dissolution studies, and particle size analysis were performed to evaluate changes in nystatin crystallinity. Antifungal activity and anti-biofilm efficacy were assessed by microbiological techniques. The results for nystatin solid dispersions showed that the enhancement of antifungal activity may be related to the high proportions of maltodextrins. Anti-biofilm assays showed a significant reduction (more than 80%) on biofilm formation with SD-N:MD [1:6] compared to the nystatin reference suspension. The elaboration process and physicochemical properties of SD-N:MD [1:6] could be a promising strategy for treatment of Candida biofilms.
PB MDPI
SN 1424-8247
YR 2021
FD 2021-04-22
LK https://hdl.handle.net/20.500.14352/7433
UL https://hdl.handle.net/20.500.14352/7433
LA eng
NO Ministerio de Ciencia e Innovación [MICINU]
NO Faculty of Pharmacy, University Complutense of Madrid [Research Group 910939]
DS Docta Complutense
RD 18 abr 2025