RT Journal Article
T1 Influence of zoledronic acid and pamidronate on tooth eruption in children with osteogenesis imperfecta
A1 Río Cantero, Natalia del
A1 Mourelle Martínez, Rosa
A1 Sagastizabal Cardelús, Belén
A1 Nova García, Manuel Joaquín De
AB IntroductionOsteogenesis imperfecta (OI) is a congenital disease comprising a heterogeneous group of inherited connective tissue disorders. The main treatment in children is bisphosphonate therapy. Previous animal studies have shown that bisphosphonates delay tooth eruption. The aim of this study is to determine whether patients with OI treated with pamidronate and/or zoledronic acid have a delayed eruption age compared to a control group of healthy children.MethodsAn ambispective longitudinal cohort study evaluating the age of eruption of the first stage mixed dentition in a group of children with OI (n = 37) all treated with intravenous bisphosphonates compared with a group of healthy children (n = 89). Within the study group, the correlation (Pearson correlation test) between the type of medication administered (pamidronate and/or zoledronic acid) and the chronology of tooth eruption is established, as well as the relationship between the amount of cumulative dose received and tooth eruption.ResultsThe age of eruption of the study group was significantly delayed compared to the age of eruption of the control group for molars and lateral incisors (p < 0.05). Patients who received higher cumulative doses had a delayed eruption age compared to those with lower cumulative doses (p < 0.05). There is a high positive correlation between age of delayed tooth eruption and Zoledronic acid administration.ConclusionPatients with OI have a delayed eruption of the 1st stage mixed dentition compared to a control group of healthy children. This delayed eruption is directly related to the cumulative dose of bisphosphonates and the administration of zoledronic ac.
PB Elsevier
SN 8756-3282
YR 2024
FD 2024-03-06
LK https://hdl.handle.net/20.500.14352/102192
UL https://hdl.handle.net/20.500.14352/102192
LA eng
NO Río Cantero N del, Mourelle Martínez M.R., Sagastizabal Cardelús B., Nova García J M de. Influence of zoledronic acid and pamidronate on tooth eruption in children with osteogenesis imperfecta, Bone, 2023 Mar 6; 117069
DS Docta Complutense
RD 18 jul 2024