RT Journal Article
T1 Adult-onset hypothyroidism increases ethanol consumption
A1 Echeverry Alzate, Victor
A1 Buhler, Kora Mareen Katharina
A1 Calleja Conde, Javier
A1 Huertas Rodríguez, Evelio
A1 Maldonado, Rafael
A1 Rodríguez De Fonseca, Fernando Antonio
A1 Santiago, Catalina
A1 Gómez Gallego, Santiago
A1 Santos Montes, Gregorio Ángel
A1 Giné Domínguez, Elena
A1 López Moreno, José Antonio
AB Rationale Only in Europe it can be estimated that more than 20 million of people would be affected by hypothyroidism in some moment of their life. Given that ethanol consumption is so frequent, it would be reasonable to ask what the consequences of ethanol consumption in those individuals affected by hypothyroidism are.Objectives To study the interaction between hypothyroidism and ethanol consumption.Methods We study ethanol consumption in a rat model of methyl mercaptoimidazole-induced-adult-onset hypothyroidism and thyroid T4/T3 hormone supplementation. Also, we studied the effects of ethanol on motor activity, memory, and anxiety. Results We found that hypothyroidism increased the voluntary ethanol consumption and that this was enhanced by thyroid hormone supplementation. Hypothyroidism was associated with motor hyperactivity which was prevented either by T4/T3 supplementation or ethanol. The relationship between hypothyroidism, ethanol, and anxiety was more complex. In an anxiogenic context, hypothyroidism and T4/T3 supplementation would increase immobility, an anxiety-like behavior, while in a less anxiogenic context would decrease rearing, a behavior related to anxiety. Regarding memory, acute ethanol administration did not alter episodic-like memory in hypothyroid rats. Gene expression of enzymes involved in the metabolism of ethanol, i.e., Adh1 and Aldh2, were altered by hypothyroidism and T4/T3 supplementation.Conclusions Our results suggest that hypothyroid patients would need personalized attention in terms of ethanol consumption. In addition, they point that it would be useful to embrace the thyroid axis in the study of ethanol addiction, including as a possible therapeutic target for the treatment of alcoholism and its comorbid disorders
PB Springer Link
SN 1432-2072
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/91248
UL https://hdl.handle.net/20.500.14352/91248
LA eng
NO Echeverry-Alzate V, Bühler KM, Calleja-Conde J, Huertas E, Maldonado R, Rodríguez de Fonseca F, Santiago C, Gómez-Gallego F, Santos A, Giné E, López-Moreno JA. Adult-onset hypothyroidism increases ethanol consumption. Psychopharmacology (Berl). 2019 Apr;236(4):1187-1197. doi: 10.1007/s00213-018-5123-1. Epub 2018 Nov 23. PMID: 30470859.
NO European Foundation for Alcohol Research
NO Ministerio de Sanidad (España)
NO Red de Trastornos Adictivos
DS Docta Complutense
RD 8 abr 2025