RT Journal Article
T1 The interplay between functioning problems and symptoms in first episode of psychosis: An approach from network analysis
A1 Ana Izquierdo, 
A1 María Cabello, 
A1 Itziar Leal, 
A1 Blanca Mellor-Marsá, 
A1 Miriam Ayora, 
A1 María-Fe Bravo-Ortiz, 
A1 Ángela Ibáñez, 
A1 Karina S. MacDowell, 
A1 Norberto Malpica, 
A1 Enrique Baca-García, 
A1 Natalia E. Fares-Otero, 
A1 Helena Melero, 
A1 Pilar López-García, 
A1 Covadonga M. Díaz-Caneja, 
A1 Jose Luis Ayuso-Mateos, 
A1 Manuel Durán-Cutilla, 
A1 Jessica Merchán-Naranjo, 
A1 Roberto Mediavilla-Torres, 
A1 Ainoa Muñoz-Sanjosé, 
A1 Luis Sanchez-Pastor, 
A1 Monica Dompablo, 
A1 Patricia Fernández-Martín, 
A1 Pablo Puras-Rico, 
A1 Lucía Albarracin-García, 
A1 Melero Carrasco, Helena
A1 Rodríguez Jiménez, Roberto
A1 Díaz Marsa, Marina Francisca
A1 Arango López, Celso
A1 García-Albea Martín, Julia Isabel
A1 Leza Cerro, Juan Carlos
A1 Leticia León Quismondo, 
AB The relationship between psychotic symptoms and global measures of functioning has been widely studied. No previous study has assessed so far the interplay between specific clinical symptoms and particular areas of functioning in first-episode psychosis (FEP) using network analysis methods. A total of 191 patients with FEP (age 24.45 ± 6.28 years, 64.9% male) participating in an observational and longitudinal study (AGES-CM) comprised the study sample. Functioning problems were assessed with the WHO Disability Assessment Schedule (WHODAS), whereas the Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity. Network analysis were conducted with the aim of analysing the patterns of relationships between the different dimensions of functioning and PANSS symptoms and factors at baseline. According to our results, the most important nodes were “conceptual disorganization”, “emotional withdrawal”, “lack of spontaneity and flow of conversation”, “delusions”, “unusual thought content”, “dealing with strangers” and “poor rapport”. Our findings suggest that these symptoms and functioning dimensions should be prioritized in the clinical assessment and management of patients with FEP. These areas may also become targets of future early intervention strategies, so as to improve quality of life in this population.
PB Science Direct (Elsevier)
SN 0022-3956
YR 2021
FD 2021-04
LK https://hdl.handle.net/20.500.14352/100254
UL https://hdl.handle.net/20.500.14352/100254
LA eng
NO Izquierdo A, Cabello M, Leal I, Mellor-Marsá B, Ayora M, Bravo-Ortiz M-F, et al. The interplay between functioning problems and symptoms in first episode of psychosis: An approach from network analysis. J Psychiatr Res [Internet]. 2021;136:265–73.
DS Docta Complutense
RD 18 jul 2024