RT Journal Article
T1 The interplay between functioning problems and symptoms in first episode of psychosis: An approach from network analysis
A1 Izquierdo, Ana
A1 Cabello, María
A1 Leal, Itziar
A1 Mellor-Marsá, Blanca
A1 Ayora, Miriam
A1 Bravo Ortiz, María Fe
A1 Ibáñez, Ángela
A1 Mac-Dowell Mata, Karina Soledad
A1 Malpica, Norberto
A1 Baca García, Enrique
A1 Fares Otero, Natalia E.
A1 Melero, Helena
A1 López García, Pilar
A1 Díaz Caneja, Covadonga M.
A1 Ayuso Mateos, Jose Luis
A1 Durán Cutilla, Manuel
A1 Merchán Naranjo, Jessica
A1 Mediavilla Torres, Roberto
A1 Muñoz Sanjosé, Ainoa
A1 Sanchez Pastor, Luis
A1 Dompablo, Monica
A1 Fernández Martín, Patricia
A1 Puras Rico, Pablo
A1 Albarracin García, Lucía
A1 Melero Carrasco, Helena
A1 Rodríguez Jiménez, Roberto
A1 Díaz Marsa, Marina Francisca
A1 Arango López, Celso
A1 García-Albea Martín, Julia Isabel
A1 Leza Cerro, Juan Carlos
A1 León Quismondo, Leticia
AB The relationship between psychotic symptoms and global measures of functioning has been widely studied. No previous study has assessed so far the interplay between specific clinical symptoms and particular areas of functioning in first-episode psychosis (FEP) using network analysis methods. A total of 191 patients with FEP (age 24.45 ± 6.28 years, 64.9% male) participating in an observational and longitudinal study (AGES-CM) comprised the study sample. Functioning problems were assessed with the WHO Disability Assessment Schedule (WHODAS), whereas the Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity. Network analysis were conducted with the aim of analysing the patterns of relationships between the different dimensions of functioning and PANSS symptoms and factors at baseline. According to our results, the most important nodes were “conceptual disorganization”, “emotional withdrawal”, “lack of spontaneity and flow of conversation”, “delusions”, “unusual thought content”, “dealing with strangers” and “poor rapport”. Our findings suggest that these symptoms and functioning dimensions should be prioritized in the clinical assessment and management of patients with FEP. These areas may also become targets of future early intervention strategies, so as to improve quality of life in this population.
PB Science Direct (Elsevier)
SN 0022-3956
YR 2021
FD 2021-04
LK https://hdl.handle.net/20.500.14352/100254
UL https://hdl.handle.net/20.500.14352/100254
LA eng
NO Izquierdo A, Cabello M, Leal I, Mellor-Marsá B, Ayora M, Bravo-Ortiz M-F, et al. The interplay between functioning problems and symptoms in first episode of psychosis: An approach from network analysis. J Psychiatr Res [Internet]. 2021;136:265–73.
DS Docta Complutense
RD 14 dic 2025