RT Journal Article
T1 Fine tuned aminal cleavage: A concise route to differentially protected enantiopure syn-α,β-diaminoesters
A1 Viso Beronda, Alma
A1 Fernández de la Pradilla, Roberto
A1 Flores Aguilar-Amat, Aída
A1 López Rodríguez, María Luz
A1 García Suárez, Ana Beatriz
A1 Alonso Rodríguez, Marta Isabel
AB A survey of routes for aminal cleavage of N-sulfinylimidazolidines has been carried out, and selective conditions to cleave the aminal moiety while preserving the sulfinamide group unaltered have been found. Thus, the treatment of enantiopure N-sulfinylimidazolidines with aqueous H3PO4 in THF affords enantiopure N-sulfinyldiamino esters in excellent yields, while the presence of MeOH as cosolvent allows for the simultaneous removal of the sulfinamide group and aminal cleavage. The behavior of these substrates in a variety of chemical transformations has been explored.
PB American Chemical SOciety
SN 0022-3263
YR 2004
FD 2004-01-27
LK https://hdl.handle.net/20.500.14352/98460
UL https://hdl.handle.net/20.500.14352/98460
LA eng
NO Comunidad de Madrid
NO Madrid Ciencia y Tecnología
DS Docta Complutense
RD 24 abr 2025