RT Journal Article
T1 Evolutions of spontaneous portosystemic shunts over time and following aetiological intervention in patients with cirrhosis
A1 Vidal González, Judit
A1 Poncela, Marta
A1 Ramón, Enrique
A1 García Martínez, Rita
AB Background & AimsSpontaneous portosystemic shunts (SPSS) develop frequently in cirrhosis. Changes over time and the effect of aetiological interventions on SPSS are unknown, so we aimed to explore the effect of these variables on SPSS evolution.MethodsPatients with cirrhosis from the Baveno VI-SPSS cohort were selected provided a follow-up abdominal CT or MRI scan was available. Clinical and laboratory data were collected at baseline and follow-up. Imaging tests were reviewed to evaluate changes in the presence and size of SPSS (large (L)-SPSS was ≥8 mm) over time. Regarding alcohol- or HCV-related cirrhosis, two populations were defined: cured patients (abstinent from alcohol or successful HCV therapy), and non-cured patients.ResultsA total of 617 patients were included. At baseline SPSS distribution was 22% L-SPSS, 30% small (S)-SPSS, and 48% without (W)-SPSS. During follow-up (median follow-up of 63 months), SPSS distribution worsened: L-SPSS 26%, S-SPSS 32%, and W-SPSS 42% (p <0.001). Patients with worse liver function during follow-up showed a simultaneous aggravation in SPSS distribution. Non-cured patients (n = 191) experienced a significant worsening in liver function, more episodes of liver decompensation and lower transplant-free survival compared to cured patients (n = 191). However, no differences were observed regarding SPSS distribution at inclusion and at follow-up, with both groups showing a trend to worsening. Total shunt diameter increased more in non-cured (52%) than in cured patients (28%). However, total shunt area (TSA) significantly increased only in non-cured patients (74 to 122 mm2, p <0.001).ConclusionsThe presence of SPSS in cirrhosis increases over time and parallels liver function deterioration. Aetiological intervention in these patients reduces liver-related complications, but SPSS persist although progression is decreased.
PB Elsevier
YR 2024
FD 2024-02-01
LK https://hdl.handle.net/20.500.14352/115739
UL https://hdl.handle.net/20.500.14352/115739
LA eng
NO Evolution of spontaneous portosystemic shunts over time and following aetiological intervention in patients with cirrhosis Vidal-González, Judit et al. JHEP Reports, Volume 6, Issue 2, 100977
NO Fondos FEDER
NO European Commission
NO Instituto de Salud Carlos III (España)
DS Docta Complutense
RD 7 abr 2025