RT Journal Article
T1 Self-propelled enzyme-controlled IR-mesoporous silica Janus nanomotor for smart delivery
A1 Mayol Hornero, Beatriz
A1 Prádana López, Sandra
A1 García, Alba
A1 de la Torre, Cristina
A1 Díez, Paula
A1 Villalonga, Anabel
A1 Anillo, Carlos
A1 Vilela García, Diana
A1 Sánchez Sánchez, Alfredo
A1 Martínez Ruiz, María Paloma
A1 Martínez Máñez, Ramón
A1 Villalonga Santana, Reynaldo
AB Here, we report the preparation of a novel Janus nanoparticle with opposite Ir and mesoporous silica nanoparticles through a partial surface masking with toposelective modification method. This nanomaterial was employed to construct an enzyme-powered nanomachine with self-propulsion properties for on-command delivery. The cargo-loaded nanoparticle was provided with a pH-sensitive gate and unit control at the mesoporous face by first attaching boronic acid residues and further immobilization of glucose oxidase through reversible boronic acid esters with the carbohydrate residues of the glycoenzyme. Addition of glucose leads to the enzymatic production of H2O2 and gluconic acid, being the first compound catalytically decomposed at the Ir nanoparticle face producing O2 and causing the nanomachine propulsion. Gluconic acid leads to a pH reduction at the nanomachine microenvironment causing the disruption of the gating mechanism with the subsequent cargo release. This work demonstrates that enzyme-mediated self-propulsion improved release efficiency being this nanomotor successfully employed for the smart release of Doxorubicin in HeLa cancer cells.
PB Elsevier
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/129581
UL https://hdl.handle.net/20.500.14352/129581
LA eng
NO Beatriz Mayol, Sandra Pradana-López, Alba García, Cristina de la Torre, Paula Díez, Anabel Villalonga, Carlos Anillo, Diana Vilela, Alfredo Sánchez, Paloma Martínez-Ruiz, Ramón Martínez-Máñez, Reynaldo Villalonga, Self-propelled enzyme-controlled IR-mesoporous silica Janus nanomotor for smart delivery, Journal of Colloid and Interface Science, Volume 671, 2024, Pages 294-302, ISSN 0021-9797, https://doi.org/10.1016/j.jcis.2024.05.134.
NO Spanish Ministry of Economy and Competitiveness
NO Spanish Ministry for Science and Innovation
NO Instituto de Salud Carlos III
NO Generalitat Valenciana
NO Complutense University of Madrid
DS Docta Complutense
RD 19 mar 2026