RT Journal Article
T1 Bone fractures after cardiac transplantation
A1 Luaces Méndez, María
A1 Crespo-Leiro, María Generosa
A1 Paniagua-Martín, María Jesús
A1 García de Lara, Juan
A1 Rivas, Raquel Marzoa
A1 Piñón-Esteban, Pablo
A1 Cursak, Guillermo
A1 Ríos, Ramón
A1 Leira, Carmen Naya
A1 Alonso-Martín, Joaquín Jesús
A1 Castro Beiras, Alfonso
AB Objective: Bone loss and bone fractures are disabling complications after heart transplantation. Severe bone loss happens mainly during the first year posttransplantation. Steroids and cyclosporine alter bone metabolism in several ways. To counterbalance these effects, antiresorptive therapy is provided to these patients. The objective of this study was to assess the frequency of bone fractures after heart transplantation, considering previous comorbidities, immunosuppressive therapy, and osteoprotective treatment.Methods: From 1993 to 2005, 443 consecutive heart transplant recipients were followed for the occurrence of bone fractures, immunosuppressive therapy, clinical conditions, and antiresorptive treatment.Results: There were 41 fractures in 34 patients (7.6%, group I). The remainder of patients formed group II. Fractures commonly involved the lumbar spine. Postmenopausal women had more fractures than other patients (20.6% vs 7.8%, P = .02). When the initial immunosuppressive regimen included tacrolimus, fractures did not happen (P = .01, vs other regimens). Osteoprotective therapy was administered to 91.2% of patients in group I and 79% in group II (P = .08). Mean interval from transplantation to the first fracture was 1131.5 days. Overweight patients had a 61.8% incidence of fracture.Conclusions: Our series showed a low frequency of bone fractures. Postmenopausal women and overweight patients had more fractures. An initial immunosuppressive regimen using tacrolimus was associated with lower fracture rates.
PB Elsevier
SN 0041-1345
YR 2007
FD 2007
LK https://hdl.handle.net/20.500.14352/101133
UL https://hdl.handle.net/20.500.14352/101133
LA eng
NO Luaces M, Crespo Leiro MG, Paniagua Martin MJ, de Lara JG, Rivas RM, Piñon Esteban P, Cursak G, Ríos R, Leira CN, Alonso JJ, Beiras AC. Bone fractures after cardiac transplantation. Transplant Proc. 2007 Sep;39(7):2393-6. doi: 10.1016/j.transproceed.2007.07.063. PMID: 17889200.
DS Docta Complutense
RD 11 abr 2025