RT Journal Article
T1 Immunolocalisation of P2Y receptors in the rat eye
A1 Pintor Just, Jesús Jerónimo
A1 Sánchez Nogueiro, Jesús
A1 Irazu, Marta
A1 Mediero Muñoz, Aránzazu
A1 Peláez García, María Teresa
A1 Peral Cerda, María Asunción
AB Nucleotides present an important role in ocular physiology which has been demonstrated by recent works that indicate their involvement in many ocular processes. P2Y are important among P2 receptors since they can control tear production, corneal wound healing, aqueous humour dynamics and retinal physiology. Commercial antibodies have allowed us to investigate the distribution of P2Y receptors in the cornea, anterior and posterior chamber of the eye and retina. The P2Y1 receptor was present mainly in cornea, ciliary processes, and trabecular meshwork. The P2Y2 receptors were present in cornea, ciliary processes and retinal pigmented epithelium. P2Y4 was present in cornea, ciliary processes, photoreceptors, outer plexiform layer and ganglion cell layer. The P2Y6 presented almost an identical distribution as the P2Y4 receptor. The P2Y11 was also detectable in the retinal pigmented epithelium. The detailed distribution of the receptors clearly supports the recent findings indicating the relevant role of nucleotides in the ocular function.
PB Springer
SN 1573-9538
YR 2004
FD 2004
LK https://hdl.handle.net/20.500.14352/51992
UL https://hdl.handle.net/20.500.14352/51992
LA eng
NO Pintor Just, J. J., Sánchez Nogueiro, J., Irazu, M. et al. «Immunolocalisation of P2Y Receptors in the Rat Eye». Purinergic Signalling, vol. 1, n.o 1, diciembre de 2004, pp. 83-90. Springer Link, https://doi.org/10.1007/s11302-004-5072-5.
NO En Open Access en la web del editor. Versión en abierto en PMC.
NO Ministerio de Educación, Formación Profesional y Deportes (España)
NO Fondo Europeo de Desarrollo Regional
DS Docta Complutense
RD 6 abr 2025