RT Journal Article
T1 Magnesium substitution in brushite cements for enhanced bone tissue regeneration
A1 Cabrejos-Azama, Jatsué
A1 Hamdan Alkhraisat, Mohammad
A1 Rueda, Carmen
A1 Torres García-Denche, Jesús
A1 Blanco, Luis
A1 López-Cabarcos, Enrique
AB We have synthesized calcium phosphate cements doped with different amounts of magnesium (Mg-CPC)with a twofold purpose: i)to evaluate in vitro the osteoblast cell response to this material and ii) to compare the bone regeneration capacity of the doped material with a calcium cement prepared without magnesium (CPC). Cell proliferation and in vivo response increased in the Mg-CPC's in comparison with CPC. The Mg-CPC's have promoted higher new bone formation than the CPC (p<0.05). The cytocompatibility and histomorfometric analysis performed in the rabbit calvaria showed that the incorporation of magnesium ions in CPC improves osteoblasts proliferation and provides higher new bone formation. The development of a bone substitute with controllable biodegradable properties and improved bone regeneration can be considered a step toward personalized therapy that can adapt to patient needs and clinical situations.
PB Elsevier
SN 0928-4931
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/34056
UL https://hdl.handle.net/20.500.14352/34056
LA eng
NO Ministerio de Ciencia e Innovación
DS Docta Complutense
RD 6 may 2024