RT Journal Article
T1 Review: Could neurotransmitters influence neurogenesis and neurorepair after stroke?
A1 Sánchez-Mendoza, Eduardo
A1 Bellver-Landete, Victor
A1 Merino Martín, José Joaquín
A1 González, Pilar
A1 Martínez-Murillo, Ricardo
A1 Oset Gasque, María Jesús
AB Brain ischaemia and reperfusion produce alterations in the microenvironment of the parenchyma, including ATP depletion, ionic homeostasis alterations, inflammation, release of multiple cytokines and abnormal release of neurotransmitters. As a consequence, the induction of proliferation and migration of neural stem cells is redirected towards the peri-infarct region. The success of new neurorestorative treatments for damaged brain implies the need to describe with greater accuracy the mechanisms in charge of regulating adult neurogenesis, under both physiological and pathological conditions. Recent evidence demonstrates that many neurotransmitters, glutamate in particular, control the subventricular zone (SVZ), thus being part of the complex signal network that exerts a remarkable influence on the production of new neurones. Neurotransmitters provide a link between brain activity and SVZ neurogenesis. Therefore, a deeper knowledge of the role of neurotransmitters systems, such as glutamate and its transporters, in adult neurogenesis, may prove a valuable tool to be utilized as a neurorestorative therapy in this pathology.
PB Wiley
SN 0305-1846
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/116377
UL https://hdl.handle.net/20.500.14352/116377
LA eng
NO Sánchez-Mendoza E, Bellver-Landete V, Merino JJ, González MP, Martínez-Murillo R, Oset-Gasque MJ. Review: Could neurotransmitters influence neurogenesis and neurorepair after stroke? Neuropathol Appl Neurobiol. 2013 Dec;39(7):722-35. doi: 10.1111/nan.12082. PMID: 23941684.
NO Instituto de Salud Carlos III
NO Universidad Complutense de Madrid
NO Ministerio de Ciencia (España)
DS Docta Complutense
RD 6 abr 2025