RT Journal Article
T1 Differences in maternal and paternal age between schizophrenia and other psychiatric disorders
A1 López Castroman, Jorge
A1 Delgado Gómez, David
A1 Carballo Belloso, Juan José
A1 Fernández Navarro, Pablo
A1 Pérez Rodriguez, Mercedes
A1 Basurte Villamor, Ignacio
A1 Ferré Navarrete, Francisco
A1 Morant Ginestar, Consuelo
A1 Currier, Dianne
A1 Reyes Torres, Marta
A1 Navío Acosta, María Mercedes
A1 Saiz Ruiz, Jerónimo
A1 Jiménez Arriero, Miguel Ángel
A1 Baca García, Enrique
AB Advanced parental age has been shown to increase offspring risk for a number of neuropsychiatric disorders including schizophrenia and Down's syndrome. Other psychiatric disorders have been less studied with respect to the effect of parental age on offspring risk. In this study we examine if advanced parental age increased risk for ICD-10 diagnoses. We hypothesized that advanced parental age would increase risk for offspring psychotic disorders and mental retardation but not other ICD-10 diagnoses. We examined follow-up data for 30,965 subjects treated in outpatient psychiatric facilities between 1980 and 2007. Subjects were younger than 18 years of age at their first outpatient visit. A comparison group was obtained from data on registered births in Spain from 1975. We compared parental age (maternal, paternal, combined) across diagnostic categories using ANOVA and logistic regression was used to estimate the risk of psychopathology in the offspring with advanced parental age (maternal, paternal, combined). Maternal and paternal ages were higher for subjects diagnosed with mental retardation. Risk for psychotic disorders showed a significant linear increase only with advancing maternal age, and not paternal age as is more often reported.
PB Elsevier
SN 0920-9964
YR 2010
FD 2010-02-02
LK https://hdl.handle.net/20.500.14352/127335
UL https://hdl.handle.net/20.500.14352/127335
LA eng
NO Lopez-Castroman J, Gómez DD, Belloso JJ, Fernandez-Navarro P, Perez-Rodriguez MM, Villamor IB, Navarrete FF, Ginestar CM, Currier D, Torres MR, Navio-Acosta M, Saiz-Ruiz J, Jimenez-Arriero MA, Baca-Garcia E. Differences in maternal and paternal age between schizophrenia and other psychiatric disorders. Schizophr Res. 2010 Feb;116(2-3):184-90. doi: 10.1016/j.schres.2009.11.006.
NO Comunidad Autónoma de Madrid
NO Universidad Autónoma de Madrid
NO Instituto de Salud Carlos III (España)
NO Fundacion  Española de Psiquiatria y Salud Mental
NO Koplowitz Foundation
NO Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM.
DS Docta Complutense
RD 24 dic 2025