RT Journal Article
T1 Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain
A1 Cárdenas Cárdenas, Nivia
A1 Martín, Virginia
A1 Arroyo Rodríguez, Rebeca
A1 López, Mario
A1 Carrera, Marta
A1 Badiola, Carlos
A1 Jiménez Quintana, Esther Antonia
A1 Rodríguez Gómez, Juan Miguel
AB Acute otitis media (AOM) is one of the most common bacterial infections in children. Empiric antibiotherapy leads to increasing antimicrobial resistance rates among otopathogens and may impair the correct development of the microbiota in early life. In this context, probiotics seem to be an attractive approach for preventing recurrent AOM (rAOM) through the restoration of the middle ear and nasopharyngeal microbiota. The aim of this study was the selection of a probiotic strain (Lactobacillus salivarius PS7), specifically tailored for its antagonism against otopathogens. Since L. salivarius PS7 was safe and displayed a strong antimicrobial activity against otopathogens, its efficacy in preventing rAOM was assessed in a trial involving 61 children suffering from rAOM. Children consumed daily ~1 × 109 CFU of L. salivarius PS7, and the number of AOM episodes were registered and compared with that observed in the previous 6 and 12 months. The microbiota of samples collected from the external auditory canal samples was quantitatively and qualitatively assessed. The number of AOM episodes during the intervention period decreased significantly (84%) when compared to that reported during the 6 months period before the probiotic intervention. In conclusion, L. salivarius PS7 is a promising strain for the prevention of rAOM in infants and children.
PB MDPI
SN 2072-6643
YR 2019
FD 2019-02-12
LK https://hdl.handle.net/20.500.14352/12530
UL https://hdl.handle.net/20.500.14352/12530
LA eng
NO Laboratorios Casen Recordati SL
DS Docta Complutense
RD 10 abr 2025