RT Journal Article
T1 Longitudinal analysis of immune function in the first 3 years of life in thymectomized neonates during cardiac surgery
A1 Mancebo Sierra, María Esther
A1 J Clemente, 
A1 J Sanchez, 
A1 Ruiz Contreras, Jesús
A1 P De Pablos, 
A1 S Cortezon, 
A1 E Romo, 
A1 Paz Artal, Estela Natividad
A1 Allende Martínez, Luis Miguel
AB <jats:title>Summary</jats:title>               <jats:p>The purpose of this study is to evaluate the effects of neonatal thymectomy in the functional capacity of the immune system. We selected a group of 23 subjects, who had undergone thymectomy in their first 30 days of life, during an intervention for congenital heart disease. Several parameters of the immune system were evaluated during their first 3 years of life. Lymphocyte populations and subpopulations (including naive, memory and effector subpopulations), T cell receptor (TCR) Vβ repertoire, response of T cells following in vitro stimulation by mitogen, quantification of immunoglobulins, TCR excision circles (TRECS) and interleukin (IL)-7 were measured. We found that neonatal thymectomy produces long-term diminution in total lymphocyte counts, especially in naive CD4+ and CD8+ T cells. Additionally, TRECS were decreased, and plasma IL-7 levels increased. A statistically significant negative correlation was found between absolute CD4+ T cells and IL-7 (r = −0·470, P = 0·02). The patients did not suffer more infectious events than healthy control children, but thymectomy in neonates resulted in a significant decrease in T lymphocyte levels and TRECS, consistent with cessation of thymopoiesis. This could produce a compromise in immune function later in life, especially if the patients suffer T cell depletion and need a reconstitution of immune function.</jats:p>
PB Oxford Academic
SN 0009-9104
SN 1365-2249
YR 2008
FD 2008-09-22
LK https://hdl.handle.net/20.500.14352/98770
UL https://hdl.handle.net/20.500.14352/98770
LA eng
NO Mancebo E, Clemente J, Sanchez J, Ruiz-Contreras J, De Pablos P, Cortezon S, Romo E, Paz-Artal E, Allende LM. Longitudinal analysis of immune function in the first 3 years of life in thymectomized neonates during cardiac surgery. Clin Exp Immunol. 2008 Dec;154(3):375-83. doi: 10.1111/j.1365-2249.2008.03771.x. Epub 2008 Sep 22. PMID: 18811694; PMCID: PMC2633228.
DS Docta Complutense
RD 9 abr 2025