RT Journal Article
T1 NAFLD and AATD Are Two Diseases with Unbalanced Lipid Metabolism: Similarities and Differences
A1 Pérez Luz, Sara
A1 Matamala, Nerea
A1 Gómez-Mariano, Gema
A1 Janciauskiene, Sabina
A1 Martínez-Delgado, Beatriz
AB Non-alcoholic fatty liver disease (NAFLD) is a type of steatosis commonly associated with obesity, dyslipidemia, hypertension, and diabetes. Other diseases such as inherited alpha-1 antitrypsin deficiency (AATD) have also been related to the development of liver steatosis. The primary reasons leading to hepatic lipid deposits can be genetic and epigenetic, and the outcomes range from benign steatosis to liver failure, as well as to extrahepatic diseases. Progressive hepatocellular damage and dysregulated systemic immune responses can affect extrahepatic organs, specifically the heart and lungs. In this review, we discuss the similarities and differences between the molecular pathways of NAFLD and AATD, and the putative value of hepatic organoids as novel models to investigate the physio pathological mechanisms of liver steatosis.
PB MDPI
YR 2023
FD 2023-07-12
LK https://hdl.handle.net/20.500.14352/102048
UL https://hdl.handle.net/20.500.14352/102048
LA eng
NO Perez-Luz, S.; Matamala, N.; Gomez-Mariano, G.; Janciauskiene, S.; Martínez-Delgado, B. NAFLD and AATD Are Two Diseases with Unbalanced Lipid Metabolism: Similarities and Differences. Biomedicines 2023, 11, 1961. https://doi.org/10.3390/ biomedicines11071961
NO Author Contributions: Conceptualization, S.P.-L. and S.J.; resources, S.J., N.M. and G.G.-M.; writing— original draft preparation, S.P.-L. and S.J.; review and editing, N.M., G.G.-M., S.J. and B.M.-D.; supervision, B.M.-D. and S.J.; funding acquisition, B.M.-D. All authors have read and agreed to the published version of the manuscript.
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 30 dic 2025