RT Journal Article
T1 BODIPY doping of covalent organic frameworks-based nanomaterials A novel strategy towards biomedical applications
T2 Dopaje con BODIPY de nanomateriales basados en redes orgánicas covalentes Una nueva estrategia para aplicaciones biomédicas
A1 Suárez-Blas, Fatima
A1 Martínez-Fernández, Marcos
A1 Prieto Castañeda, Alejandro
A1 Prieto-Castañeda, Alejandro
A1 García-Fernández, Alba
A1 Martínez, José I.
A1 Ramos, María Mar
A1 Ortiz, María
A1 Ramón Martínez-Máñez, 
A1 Segura Castedo, José Luis
AB Covalent organic Frameworks (COFs) are a class of crystalline macromolecular materials build-up by monomers with specific symmetries or functionalities. There are important limitations in the synthesis of highly ordered COFs, such as the shape and packing of the building blocks. Thus, the presence of fluorine atoms that lie perpendicular to the bisecting plane of BODIPY derivatives together with the presence of four bulky methyl groups could hinder the crystallization process in COF synthesis. For that reason, BODIPY-based COFs are rarely incorporated to COF networks. In this work, following the mixed linker strategy, a pre-synthetic method to dope COF structures with BODIPY units was developed. The materials have been processed into fluorescent Covalent Organic Nanosheets (CONs) with defined particle-size distributions around 100 nm, suitable for cellular biomedical applications. The viability of the CONs was evaluated using Sk-Mel-103 cells, demonstrating the internalization showing 100% cell viability. We envisage that this work could accelerate the discovery of new COF-based materials for biomedical sciences
PB Elsevier
SN 0143-7208
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/100313
UL https://hdl.handle.net/20.500.14352/100313
LA eng
NO Suárez-Blas, F., Martínez-Fernández, M., Prieto-Castañeda, A., García-Fernández, A., Martínez, J. I., Ramos, M. M., ... & Segura, J. L. (2023). BODIPY doping of covalent organic frameworks-based nanomaterials: A novel strategy towards biomedical applications. Dyes and Pigments, 219, 111561.
NO This work was financially supported by Spanish MICINN (PID2019-106268GB-C33, TED2021-129886B-C43, PID2020-114755GB-C32, PID2020-113142RB-C21 and PLEC2021-007906), as well as by project PID2021-126304OB-C41 via MCIN/AEI/10.13039/501100011033/, by European Regional Development Fund - A way of doing Europe and by the Generalitat Valenciana (CIPROM/2021/007). J.I.M. also acknowledges funding from EU via the European Graphene Flagship (Grant Graphene Core3 881603) and Comunidad de Madrid (Grants S2018/NMT-4367 and Y2020/NMT-6469).
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Generalitat Valenciana
NO Comunidad de Madrid
NO European Commission
DS Docta Complutense
RD 6 abr 2025