RT Journal Article
T1 Nanoparticles for multimodal antivascular therapeutics: Dual drug release, photothermal and photodynamic therapy
A1 Paris, Juan L.
A1 Villaverde Cantizano, Gonzalo
A1 Gómez Graña, Sergio
A1 Vallet Regí, María Dulce Nombre
AB The poor delivery of nanoparticles to target cancer cells hinders their success in the clinical setting. In this work, an alternative target readily available for circulating nanoparticles has been selected to eliminate the need for nanoparticle penetration in the tissue: the tumor blood vessels. A tumor endotheliumtargeted nanoparticle (employing an RGD-containing peptide) capable of co-delivering two anti-vasculardrugs (one anti-angiogenic drug and one vascular disruption agent) is here presented. Furthermore, the nanodevice presents two additional anti-vascular capabilities upon activation by Near-Infrared light: provoking local hyperthermia (by gold nanorods in the system) and generating toxic reactive oxygen species (by the presence of a photosensitizer). RGD-targeting is shown to increase uptake by HUVEC cells, and while the nanoparticles are shown not to be toxic for these cells, upon Near-Infrared irradiation their almost complete killing is achieved. The combination of all four therapeutic modalities is then evaluated in an ex ovo fibrosarcoma xenograft model, which shows a significant reduction in the number of blood vessels irrigating the xenografts when the nanoparticles are present, as well as the destruction of the existing blood vessels upon irradiation. These results suggest that the combination of different antivascular therapeutic strategies in a single nanocarrier appears promising and should be further explored in the future.
SN 1742-7061
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/98121
UL https://hdl.handle.net/20.500.14352/98121
LA eng
NO European Commission
DS Docta Complutense
RD 20 abr 2025