RT Journal Article
T1 Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
A1 Sánchez-Puebla Fernández, Lidia
A1 Hoz Montañana, María Rosa De
A1 García Martín, Elena Salobrar
A1 Arias Vázquez, Alberto
A1 González Jiménez, María
A1 Ramírez Sebastián, Ana Isabel
A1 Fernández Albarral, José
A1 Matamoros Felipe, José Antonio
A1 Elvira Hurtado, Lorena
A1 Saido, Takaomi C
A1 Saito, Takashi
A1 Nieto Vaquero, Carmen
A1 Cuartero Desviat, María Isabel
A1 Moro Sánchez, María Ángeles
A1 Salazar Corral, Juan José
A1 López Cuenca, Inés
A1 Ramírez Sebastián, José Manuel
AB In Alzheimer’s disease (AD), transgenic mouse models have established links between abnormalities in the retina and those in the brain. APPNL-F/NL-F is a murine, humanized AD model that replicates several pathological features observed in patients with AD. Research has focused on obtaining quantitative parameters from optical coherence tomography (OCT) in AD. The aim of this study was to analyze, in a transversal case-control study using manual retinal segmentation via SD-OCT, the changes occurring in the retinal layers of the APPNL/F-NF/L AD model in comparison to C57BL/6J mice (WT) at 6, 9, 12, 15, 17, and 20 months of age. The analysis focused on retinal thickness in RNFL-GCL, IPL, INL, OPL, and ONL based on the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors. Both APPNL-F/NL-F-model and WT animals exhibited thickness changes at the time points studied. While WT showed significant changes in INL, OPL, and ONL, the AD model showed changes in all retinal layers analyzed. The APPNL-F/NL-F displayed significant thickness variations in the analyzed layers except for the IPL compared to related WT. These thickness changes closely resembled those found in humans during preclinical stages, as well as during mild and moderate AD stages, making this AD model behave more similarly to the disease in humans.
PB MDPI
SN 1661-6596
YR 2024
FD 2024-07-27
LK https://hdl.handle.net/20.500.14352/109284
UL https://hdl.handle.net/20.500.14352/109284
LA eng
NO Sánchez-Puebla, L.; de Hoz, R.; Salobrar-García, E.; Arias-Vázquez, A.; González-Jiménez, M.; Ramírez, A.I.; Fernández-Albarral, J.A.; Matamoros, J.A.; Elvira-Hurtado, L.; Saido, T.C.; et al. Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease. Int. J. Mol. Sci. 2024, 25, 8221. https://doi.org/10.3390/ijms25158221
NO Ministerio de Ciencia e Innovación (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 6 abr 2025