RT Journal Article
T1 Cobalt(I)-Catalyzed (3 + 2 + 2) Cycloaddition between Alkylidenecyclopropanes, Alkynes, and Alkenes
A1 Da Concepción, Eduardo
A1 Lázaro Milla, Carlos
A1 Fernández López, Israel
A1 Mascareñas, José
A1 López, Fernando
AB Cobalt(I) catalysts equipped with bisphosphine ligands can be used to promote formal (3 + 2 + 2) intramolecular cycloadditions of enynylidenecyclopropanes of type 1. The method provides synthetically appealing 5,7,5-fused tricyclic systems in good yields and with complete diastereo- and chemoselectivity. Interestingly, its scope differs from that of previously reported annulations based on precious metal catalysts, specifically rhodium and palladium. Noticeably, density functional theory calculations confirm that the mechanism of the reaction is also different from those proposed for these other catalysts.
PB American Chemical Society
SN 1523-7060
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/98146
UL https://hdl.handle.net/20.500.14352/98146
LA eng
NO Da Concepción, Eduardo, et al. «Cobalt(I)-Catalyzed (3 + 2 + 2) Cycloaddition between Alkylidenecyclopropanes, Alkynes, and Alkenes». Organic Letters, vol. 25, n.o 46, noviembre de 2023, pp. 8372-76. https://doi.org/10.1021/acs.orglett.3c03511.
NO Ministerio de Ciencia Innovación (España)
NO Xunta de Galicia
NO European Commission
DS Docta Complutense
RD 29 abr 2025