%0 Journal Article
%A Largo de la Torre, Andrea
%A Ferré Pérez, Ignacio
%A Sánchez Sánchez, Roberto
%A Regidor Cerrillo, Javier
%A Ortega Mora, Luis Miguel
%T Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
%D 2025
%@ 0928-4249
%U https://hdl.handle.net/20.500.14352/120104
%X Type II reference isolates of Toxoplasma gondii are widely used in animal toxoplasmosis models, but studies with Type III isolates remain scarce. In addition, these methods often rely on laboratory-adapted parasite stages that may not reflect natural infection. This study presents a new murine model based on an oral infection with oocysts from a recently obtained Type III isolate, TgShSp24, which exhibited remarkable morbidity and a distinct tissue distribution during chronic infection, differing from the recently obtained Type II isolate TgShSp1. This novel model aims to better mimic natural infection and provides a valuable tool for testing drugs and vaccines.
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