RT Journal Article
T1 Biomagnetic biomarkers for dementia: A pilot multicentre study with a recommended methodological framework for magnetoencephalography
A1 Hughes, Laura E.
A1 Henson, Richard N.
A1 Pereda, Ernesto
A1 Quinn, Andrew J.
A1 Woolrich, Mark W.
A1 Nobre, Anna C.
A1 Rowe, James B.
A1 López Sanz, David
A1 Maestu Unturbe, Fernando
A1 Bruña Fernández, Ricardo
A2 Jovicich, Jorge
A2 Frisoni, Giovanni B.
AB IntroductionAn increasing number of studies are using magnetoencephalography (MEG) to study dementia. Here we define a common methodological framework for MEG resting-state acquisition and analysis to facilitate the pooling of data from different sites.MethodsTwo groups of patients with mild cognitive impairment (MCI, n = 84) and healthy controls (n = 84) were combined from three sites, and site and group differences inspected in terms of power spectra and functional connectivity. Classification accuracy for MCI versus controls was compared across three different types of MEG analyses, and compared with classification based on structural MRI.ResultsThe spectral analyses confirmed frequency-specific differences in patients with MCI, both in power and connectivity patterns, with highest classification accuracy from connectivity. Critically, site acquisition differences did not dominate the results.DiscussionThis work provides detailed protocols and analyses that are sensitive to cognitive impairment, and that will enable standardized data sharing to facilitate large-scale collaborative projects.
SN 2352-8729
SN 2352-8729
YR 2019
FD 2019-06-14
LK https://hdl.handle.net/20.500.14352/93455
UL https://hdl.handle.net/20.500.14352/93455
LA eng
DS Docta Complutense
RD 18 ago 2025