RT Journal Article
T1 Imaging plasma membrane phase behaviour in live cells using a thiophene-based molecular rotor
A1 Dent, Michael R.
A1 López Duarte, Ismael
A1 Dickson, Callum J.
A1 Chairatana, Phoom
A1 Anderson, Harry L.
A1 Gould, Ian R.
A1 Wylie, Douglas
A1 Vyšniauskas, Aurimas
A1 Brooks, Nicholas J.
A1 Kuimova, Marina K.
AB Molecular rotors have emerged as versatile probes of microscopic viscosity in lipid bilayers, although it has proved difficult to find probes that stain both phases equally in phase-separated bilayers. Here, we investigate the use of a membrane-targeting viscosity-sensitive fluorophore based on a thiophene moiety with equal affinity for ordered and disordered lipid domains to probe ordering and viscosity within artificial lipid bilayers and live cell plasma membranes.
PB Royal Society of Chemistry
SN 1359-7345
SN 1364-548X
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/114908
UL https://hdl.handle.net/20.500.14352/114908
LA eng
DS Docta Complutense
RD 7 abr 2025