RT Journal Article
T1 Absorption of the Wolffian duct and duplicated ureter by the urogenital sinus: morphological study using human fetuses and embryos
A1 Naito, Michiko
A1 Hinata, Nobuyuki
A1 Rodríguez Vázquez, José Francisco
A1 Murakami, Gen
A1 Aizawa, Shin
A1 Fujisawa, Masato
AB ObjectivesTo describe the embryological origin of the duplicated ureter and to investigate whether the urogenital sinus absorbs not only the Wolffian duct (WD) but also the ureter.Materials and MethodsDuring studies using sections of human fetuses (45 specimens), we incidentally found a specific type of ureteric duplication (at ~7 weeks) in which two unilateral ureters joined at the vesico‐ureteric junction, apparently representing a morphology arising at an intermediate stage between complete and partial ureteric duplication. The existing literature lacks any photographic representation of early development of the vesico‐ureteric junction, and we therefore studied horizontal sections of 10 human embryos (at ~5–6 weeks' gestation) in which the ureter did not join the urogenital sinus (future bladder) but instead joined the WD (future vas deferens).ResultsThe sinus consistently showed a reversed Y‐shape, the arms of which extended posteriorly to receive the WD. When absorption of the duct into the sinus wall reached the distal end of the ureter, the arm‐like parts appeared to enlarge posteriorly for further involvement of the duct, with little or no incorporation of the ureter; therefore, the future trigone of the bladder might develop from these arm‐like parts of the sinus posterior wall. Consequently, in the case of ureteric duplication included in the present study, it is considered that the ureters would probably have merged with the WD at closely adjacent sites.ConclusionThe present study represents the first photographic illustration of the early development of the human vesico‐ureteric junction.
PB Wiley
SN 1464-4096
SN 1464-410X
YR 2015
FD 2015-03-26
LK https://hdl.handle.net/20.500.14352/109760
UL https://hdl.handle.net/20.500.14352/109760
LA eng
NO Naito, M., Hinata, N., Rodriguez-Vazquez, J. F., Murakami, G., Aizawa, S., & Fujisawa, M. (2015). Absorption of the Wolffian duct and duplicated ureter by the urogenital sinus: morphological study using human fetuses and embryos. BJU international, 116(1), 135–141. https://doi.org/10.1111/bju.13006
DS Docta Complutense
RD 8 abr 2025