RT Journal Article
T1 Glycyrrhizinic Acid as an Antiviral and Anticancer Agent in the Treatment of Human Papillomavirus
A1 Bravo, Victoria
A1 Serrano Velasco, María
A1 Duque, Alfonso
A1 Ferragud, Juan
A1 Coronado Martín, Pluvio Jesús
AB Human papillomavirus (HPV), like any other virus, needs to penetrate the host cell and make use of its machinery to replicate. From there, HPV infection can be asymptomatic or lead to benign and premalignant lesions or even different types of cancer. HPV oncogenesis is due to the ability of the viral oncoproteins E6 and E7 to alter the control mechanisms for the growth and proliferation of host cell. Therefore, the use of agents with the ability to control these processes is essential in the search for effective treatments against HPV infections. Glycyrrhizinic acid (Gly), the active ingredient in liquorice, has been shown in numerous preclinical studies to have an antiviral and anticancer activity, reducing the expression of E6 and E7 and inducing apoptosis in cervical cancer cells. In addition, it also has antioxidant, anti-inflammatory, immunomodulatory or re-epithelializing properties that can be useful in HPV infections. This review includes the different antiviral and anticancer mechanisms described for Gly, as well as the clinical studies carried out that position it as a potential therapeutic strategy against HPV both through its topical application and by oral administration.
PB MDPI
SN 2075-4426
YR 2023
FD 2023-11-24
LK https://hdl.handle.net/20.500.14352/103504
UL https://hdl.handle.net/20.500.14352/103504
LA eng
NO Bravo, V.; Serrano, M.; Duque, A.; Ferragud, J.; Coronado, P.J. Glycyrrhizinic Acid as an Antiviral and Anticancer Agent in the Treatment of Human Papillomavirus. J. Pers. Med. 2023, 13, 1639. https:// doi.org/10.3390/jpm13121639
NO Catalysis
DS Docta Complutense
RD 10 abr 2025